Immunohistochemistry (IHC)
(Anti-Chordin antibody IHC staining of human pancreatic duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit anti-Human Chordin Polyclonal Antibody | anti-CHRD antibody
Rabbit Polyclonal to Human Chordin
Immunohistochemistry (IHC)
(Anti-Chordin antibody IHC staining of human pancreatic duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-Chordin antibody IHC staining of human pancreatic duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CHRD antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CHRD antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.)
Western Blot (WB)
(Western blot of anti-CHRD Antibody (C-term) in HepG2 cell line lysates (35 ug/lane). CHRD(arrow) was detected using the purified Pab (1:60 dilution).)
Western Blot (WB)
(Western blot of anti-CHRD Antibody (C-term) in HepG2 cell line lysates (35 ug/lane). CHRD(arrow) was detected using the purified Pab (1:60 dilution).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
CHRD: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. Belongs to the chordin family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q27
Cellular Component: extracellular space
Molecular Function: syndecan binding; heparin binding; protein binding; cytokine binding
Biological Process: BMP signaling pathway in spinal cord dorsal-ventral patterning; osteoblast differentiation; floor plate development; positive regulation of cell adhesion; mesoderm formation; forebrain development; positive regulation of mesenchymal cell proliferation; negative regulation of osteoblast differentiation; gastrulation with mouth forming second; negative regulation of cell migration; skeletal development; negative regulation of BMP signaling pathway
Research Articles on CHRD
Similar Products
Product Notes
The CHRD chrd (Catalog #AAA248426) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human Chordin reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Chordin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (10 ug/ml), WB (1:1000). Researchers should empirically determine the suitability of the CHRD chrd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Chordin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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