Rabbit anti-Human STOX1 Polyclonal Antibody | anti-STOX1 antibody

Rabbit Polyclonal to Human STOX1

Cat. Num. AAA248420

• Gene Names: STOX1; PEE4; C10orf24
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: STOX1; Polyclonal Antibody; Rabbit Polyclonal to Human STOX1; Anti-STOX1 Antibody (C-Terminus) IHC-plus; C10orf24; PEE4; Storkhead-box protein 1; Storkhead box 1; Human STOX1; anti-STOX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human STOX1. STOX1 antibody is human reactive. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. STOX1 antibody recognize the longest isoform.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 227

• Applicable Applications for anti-STOX1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: STOX1 antibody can be used for detection of STOX1 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: A 14 amino acid peptide near the carboxy terminus of human STOX1.
• Immunogen Type: Synthetic peptide
• Immunogen: STOX1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human STOX1.
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Anti-STOX1 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-STOX1 antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(Western blot analysis of STOX1 in human liver tissue lysate with STOX1 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 194328687
• NCBI GeneID: 219736
• NCBI Accession #: NP_001123631.1
• NCBI GenBank Nucleotide #: NM_001130159.2
• UniProt Accession #: Q6ZVD7; Q4F8Q6; Q5I946; Q5I947; Q5I948; Q5VX38; Q5VX39; A2A3Q9; A5D6Y7; B0QZA4; B0QZA5; B0QZA6
• Molecular Weight: 19,059 Da
• NCBI Official Full Name: storkhead-box protein 1 isoform b
• NCBI Official Synonym Full Names: storkhead box 1
• NCBI Official Symbol: STOX1
• NCBI Official Synonym Symbols: PEE4; C10orf24
• NCBI Protein Information: storkhead-box protein 1; winged-helix domain-containing protein
• UniProt Protein Name: Storkhead-box protein 1
• Protein Family: Storkhead-box protein
• UniProt Gene Name: STOX1
• UniProt Synonym Gene Names: C10orf24
• UniProt Entry Name: STOX1_HUMAN

NCBI Description

The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

STOX1: Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. The pathological mechanism of PEE4 involves the loss of function of STOX1 in the placenta. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: DNA binding

Disease: Preeclampsia/eclampsia 4