Rabbit anti-Human Arginase ii / ARG2 Polyclonal Antibody | anti-ARG2 antibody

Rabbit Polyclonal to Human Arginase ii / ARG2

Cat. Num. AAA248289

• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Affinity Purified
• Synonyms: Arginase ii / ARG2; Polyclonal Antibody; Rabbit Polyclonal to Human Arginase ii / ARG2; Anti-Arginase ii / ARG2 Antibody (aa180-348) IHC-plus; ARG2; Arginase II; Kidney arginase; Nonhepatic arginase; Kidney-type arginase; L-arginine ureahydrolase; Type II arginase; Arginase 2; Arginase; type II; Arginase-2; mitochondrial; L-arginine amidinohydrolase; Non-hepatic arginase; Human Arginase ii; anti-ARG2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human Arginase II / ARG2.
• Purity/Purification: Affinity Purified
• Form/Format: PBS, pH 7.4, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 354

• Applicable Applications for anti-ARG2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:20000 - 1:80000), IHC-P (10 ug/ml), WB (1:1000 - 1:2000)
• Target Species: Human
• Immunogen Description: A recombinant human ARG2 protein 180-348aa (BC001350).
• Immunogen Type: Recombinant protein
• Immunogen: Arginase ii / ARG2 antibody was raised against a recombinant human ARG2 protein 180-348aa (BC001350).
• Antigen Modification: aa180-348
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

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NCBI and Uniprot Product Information

• NCBI GI #: 4502215
• NCBI GeneID: 384
• NCBI Accession #: NP_001163.1
• NCBI GenBank Nucleotide #: NM_001172.3
• UniProt Accession #: P78540; Q6FHY8; B2R690
• Molecular Weight: 38,578 Da
• NCBI Official Full Name: arginase-2, mitochondrial
• NCBI Official Synonym Full Names: arginase 2
• NCBI Official Symbol: ARG2
• NCBI Protein Information: arginase-2, mitochondrial; kidney arginase; type II arginase; arginase, type II; nonhepatic arginase; kidney-type arginase; non-hepatic arginase; L-arginine ureahydrolase; L-arginine amidinohydrolase
• UniProt Protein Name: Arginase-2, mitochondrial
• Protein Family: Arginase
• UniProt Gene Name: ARG2
• UniProt Entry Name: ARGI2_HUMAN

NCBI Description

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

ARG2: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Belongs to the arginase family.

Protein type: Hydrolase; EC 3.5.3.1; Mitochondrial; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: metal ion binding; arginase activity

Biological Process: striated muscle contraction; arginine metabolic process; ureteric bud development; nitric oxide biosynthetic process; urea cycle