Arginase 2 Recombinant Protein | ARG2 recombinant protein

Arginase 2, Human Recombinant

Cat. Num. AAA849932

• Purity: >=95% by SDS-PAGE
• Synonyms: Arginase 2; Human Recombinant; Kidney arginase; Non-hepatic arginase; ARG2 recombinant protein

• Host: E Coli
• Purity/Purification: >=95% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
• Sequence: MGSSHHHHHHSSGLVPRGSHMVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATFTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI

• Gene Source: Human
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Related Product Information for ARG2 recombinant protein

Arginase is a manganese-containing enzyme which catalyzes the hydrolysis of arginine to ornithine and urea. It is the final enzyme of the urea cycle. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic cross-reactivity and physiologic function. The type II isoform is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. It is thought to play a role in nitric oxide and polyamine metabolism.

Product Categories/Family for ARG2 recombinant protein

Signal Transduction; Enzymes & Proteases; Proteins; Enzymes; Proteins & Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 4502215
• NCBI GeneID: 384
• NCBI Accession #: NP_001163.1
• NCBI GenBank Nucleotide #: NM_001172.3
• UniProt Accession #: P78540; Q6FHY8; B2R690
• Molecular Weight: 38,578 Da
• NCBI Official Full Name: arginase-2, mitochondrial
• NCBI Official Synonym Full Names: arginase 2
• NCBI Official Symbol: ARG2
• NCBI Protein Information: arginase-2, mitochondrial; kidney arginase; type II arginase; arginase, type II; nonhepatic arginase; kidney-type arginase; non-hepatic arginase; L-arginine ureahydrolase; L-arginine amidinohydrolase
• UniProt Protein Name: Arginase-2, mitochondrial
• Protein Family: Arginase
• UniProt Gene Name: ARG2
• UniProt Entry Name: ARGI2_HUMAN

NCBI Description

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

ARG2: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Belongs to the arginase family.

Protein type: Hydrolase; Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 3.5.3.1

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: metal ion binding; arginase activity

Biological Process: striated muscle contraction; arginine metabolic process; ureteric bud development; nitric oxide biosynthetic process; urea cycle