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Immunohistochemistry (IHC) (Anti-GPC4 / Glypican 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit GPC4 / Glypican 4 Polyclonal Antibody | anti-GPC4 antibody

Rabbit Polyclonal to Human GPC4 / Glypican 4

Gene Names
GPC4; K-glypican
Reactivity
Gorilla, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat, Dog (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
GPC4 / Glypican 4; Polyclonal Antibody; Rabbit Polyclonal to Human GPC4 / Glypican 4; Anti-GPC4 / Glypican 4 Antibody (N-Terminus) IHC-plus; GPC4; DJ900E8.1 (glypican 4); Glypican 4; Glypican proteoglycan 4; Glypican-4; K-glypican; Human GPC4; anti-GPC4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Gorilla, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat, Dog (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human GPC4 / Glypican 4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
556
Applicable Applications for anti-GPC4 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (10 - 12.5 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from N-terminus of human GPC4 / Glypican 4. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Rabbit (100%); Mouse, Rat, Dog, Panda, Platypus (94%); Opossum, Xenopus (88%).
Immunogen Type
Synthetic peptide
Immunogen
GPC4 / Glypican 4 antibody was raised against synthetic 16 amino acid peptide from N-terminus of human GPC4 / Glypican 4. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Rabbit (100%); Mouse, Rat, Dog, Panda, Platypus (94%); Opossum, Xenopus (88%).
Antigen Modification
N-Terminus
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-GPC4 / Glypican 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-GPC4 / Glypican 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPC4 / Glypican 4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-GPC4 / Glypican 4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-GPC4 antibody
Glypican 4 belongs to the glypican family of heparin sulfate proteoglycans (HSPGs) that are anchored to cell membranes by a glycosylphosphatidylinositol linkage. Glypicans may play a role in the control of cell division and growth regulation. Glypican 4 has been shown to be a receptor for endostatin a known potent antiangiogenic protein.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
54,910 Da
NCBI Official Full Name
glypican-4
NCBI Official Synonym Full Names
glypican 4
NCBI Official Symbol
GPC4
NCBI Official Synonym Symbols
K-glypican
NCBI Protein Information
glypican-4; dJ900E8.1 (glypican 4); glypican proteoglycan 4
UniProt Protein Name
Glypican-4
Protein Family
UniProt Gene Name
GPC4
UniProt Entry Name
GPC4_HUMAN

NCBI Description

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

Uniprot Description

GPC4: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system. Belongs to the glypican family.

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq26.1

Cellular Component: lysosomal lumen; proteinaceous extracellular matrix; extracellular space; Golgi lumen; integral to plasma membrane; plasma membrane; nucleus; external side of plasma membrane

Molecular Function: heparan sulfate proteoglycan binding

Biological Process: chondroitin sulfate metabolic process; cell proliferation; glycosaminoglycan biosynthetic process; phototransduction, visible light; glycosaminoglycan catabolic process; anatomical structure morphogenesis; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; retinoid metabolic process

Disease: Simpson-golabi-behmel Syndrome, Type 1; Wilms Tumor 1

Research Articles on GPC4

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Product Notes

The GPC4 gpc4 (Catalog #AAA247849) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human GPC4 / Glypican 4 reacts with Gorilla, Human, Monkey, Rabbit Predicted Reactivity: Mouse, Rat, Dog (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's GPC4 / Glypican 4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (10 - 12.5 ug/ml). Researchers should empirically determine the suitability of the GPC4 gpc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPC4 / Glypican 4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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