Rabbit GHRHR Polyclonal Antibody | anti-GHRHR antibody

Rabbit Polyclonal to Human GHRHR

Cat. Num. AAA247312

• Gene Names: GHRHR; GRFR; GHRFR; IGHD1B
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey, Dog (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GHRHR; Polyclonal Antibody; Rabbit Polyclonal to Human GHRHR; Anti-GHRHR Antibody (N-Terminus) IHC-plus; GHRFR; GRFR; IGHD1B; GRF receptor; GH-releasing hormone receptor; GHRH receptor; Ghrh-r; Human GHRHR; anti-GHRHR antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey, Dog (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GHRHR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FLJ23588 (50%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 423

• Applicable Applications for anti-GHRHR antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human GHRHR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Marmoset, Panda, Dog (94%); Zebu, Bovine (89%); Rabbit, Pig (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: GHRHR antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human GHRHR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Marmoset, Panda, Dog (94%); Zebu, Bovine (89%); Rabbit, Pig (83%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GHRHR antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GHRHR antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GHRHR antibody IHC of human pituitary, anterior. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GHRHR antibody

GHRHR, a Growth Hormone-Releasing Hormone Receptor, is involved in the proliferation and differentiation of somatotrophic pituitary cells and in disease. The GHRH receptor stimulates growth hormone (GH) secretion and synthesis in the pituitary. Mutations in this receptor cause either growth-hormone deficiency, resulting in dwarfism, or excessive production of the hormone, leading to gigantism. Four alternative splice variants have been identified that are tissue specific.

Product Categories/Family for anti-GHRHR antibody

Family: GPCR; Subfamily: Growth hormone releasing hormone

NCBI and Uniprot Product Information

• NCBI GI #: 58530851
• NCBI GeneID: 2692
• NCBI Accession #: NP_000814.2
• NCBI GenBank Nucleotide #: NM_000823.3
• UniProt Accession #: Q02643; Q99863
• Molecular Weight: 47,402 Da
• NCBI Official Full Name: growth hormone-releasing hormone receptor
• NCBI Official Synonym Full Names: growth hormone releasing hormone receptor
• NCBI Official Symbol: GHRHR
• NCBI Official Synonym Symbols: GRFR; GHRFR; IGHD1B
• NCBI Protein Information: growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor
• UniProt Protein Name: Growth hormone-releasing hormone receptor
• Protein Family: Growth hormone-releasing hormone receptor
• UniProt Gene Name: GHRHR
• UniProt Synonym Gene Names: GHRH receptor; GRF receptor; GRFR
• UniProt Entry Name: GHRHR_HUMAN

NCBI Description

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

Uniprot Description

GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Cell development/differentiation

Chromosomal Location of Human Ortholog: 7p14

Cellular Component: nuclear outer membrane; nuclear matrix; cell surface; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule

Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity

Biological Process: lactation; positive regulation of insulin-like growth factor receptor signaling pathway; response to glucocorticoid stimulus; adenylate cyclase activation; regulation of protein metabolic process; cell maturation; determination of adult life span; positive regulation of multicellular organism growth; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; positive regulation of growth hormone secretion; water homeostasis; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; somatotropin secreting cell development; hormone metabolic process; regulation of steroid hormone receptor signaling pathway

Disease: Isolated Growth Hormone Deficiency, Type Ib