Goat HEP / EPHB6 Polyclonal Antibody | anti-HEP antibody

Goat Polyclonal to Human HEP / EPHB6

Cat. Num. AAA247028

• Gene Names: EPHB6; HEP
• Reactivity: Gibbon, Chimpanzee, Dog, Gorilla, Human; Predicted Reactivity: Monkey, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: HEP / EPHB6; Polyclonal Antibody; Goat Polyclonal to Human HEP / EPHB6; Anti-HEP / EPHB6 Antibody (aa831-843) IHC-plus; EPHB6; Cekl; EPH receptor B6; Ephrin type-B receptor 6; HEP; MEP; Human HEP; anti-HEP antibody

• Host: Goat
• Reactivity: Gibbon, Chimpanzee, Dog, Gorilla, Human; Predicted Reactivity: Monkey, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human EPHB6.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 1021

• Applicable Applications for anti-HEP antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3.75 - 7.5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-EVIAHGKHTTSSD from positions 831-843 of human EPHB6 (NP_004436.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Dog (100%); Monkey, Marmoset, Panda, Horse, Rabbit, Pig (92%); Mouse, Rat (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: HEP / EPHB6 antibody was raised against synthetic peptide C-EVIAHGKHTTSSD from positions 831-843 of human EPHB6 (NP_004436.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Dog (100%); Monkey, Marmoset, Panda, Horse, Rabbit, Pig (92%); Mouse, Rat (85%).
• Antigen Modification: aa831-843
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-EPHB6 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-EPHB6 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Related Product Information for anti-HEP antibody

EPHB6 belongs to the ephrin receptor kinase family. EPHB6 does not have intrinsic tyrosine kinase activity because six invariant amino acids were have been substituted. Despite its lack of kinase activity, ligand binding results in trans-phosphorylation of EphB6 and the initiation of specific cytoplasmic signaling events.

Product Categories/Family for anti-HEP antibody

Family: Protein Kinase; Subfamily: Ephrin Receptor

NCBI and Uniprot Product Information

• NCBI GI #: 194097332
• NCBI GeneID: 2051
• NCBI Accession #: NP_004436.2
• NCBI GenBank Nucleotide #: NM_004445.3
• UniProt Accession #: O15197; Q2TB23; Q2TB24; A4D2I7; A8CDT5; D3DXD3
• Molecular Weight: 57,498 Da
• NCBI Official Full Name: ephrin type-B receptor 6
• NCBI Official Synonym Full Names: EPH receptor B6
• NCBI Official Symbol: EPHB6
• NCBI Official Synonym Symbols: HEP
• NCBI Protein Information: ephrin type-B receptor 6; tyrosine-protein kinase-defective receptor EPH-6; human kinase-defective Eph-family receptor protein
• UniProt Protein Name: Ephrin type-B receptor 6
• Protein Family: Dual specificity mitogen-activated protein kinase kinase hemipterous
• UniProt Gene Name: EPHB6
• UniProt Entry Name: EPHB6_HUMAN

NCBI Description

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

EphB6: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Kinase, protein; TK group; Eph family

Chromosomal Location of Human Ortholog: 7q33-q35

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytosol

Molecular Function: ephrin receptor activity; receptor activity; ATP binding

Biological Process: axon guidance; ephrin receptor signaling pathway; protein amino acid phosphorylation