Goat DNM3 / Dynamin 3 Polyclonal Antibody | anti-DNM3 antibody

Goat Polyclonal to Human DNM3 / Dynamin 3

Cat. Num. AAA246701

• Gene Names: DNM3; Dyna III
• Reactivity: Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: DNM3 / Dynamin 3; Polyclonal Antibody; Goat Polyclonal to Human DNM3 / Dynamin 3; Anti-DNM3 / Dynamin 3 Antibody (Internal) IHC-plus; DNM3; Dyna III; Dynamin 3; Dynamin family member; Dynamin-3; Dynamin; testicular; KIAA0820; T-dynamin; Human DNM3; anti-DNM3 antibody

• Host: Goat
• Reactivity: Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human DNM3 / Dynamin-3.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 859

• Applicable Applications for anti-DNM3 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:1000), IHC-P (2.5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-DKSVGNNKAEND from an internal region of human DNM3 / Dynamin-3 (NP_056384.2). Percent identity with other species by BLAST analysis: Human (100%), Marmoset (92%), Gorilla (83%), Mouse (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: DNM3 / Dynamin 3 antibody was raised against synthetic peptide C-DKSVGNNKAEND from an internal region of human DNM3 / Dynamin-3 (NP_056384.2). Percent identity with other species by BLAST analysis: Human (100%), Marmoset (92%), Gorilla (83%), Mouse (83%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-DNM3 / Dynamin-3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 209915561
• NCBI GeneID: 26052
• NCBI Accession #: NP_001129599.1
• NCBI GenBank Nucleotide #: NM_001136127.2
• UniProt Accession #: Q9UQ16; O14982; O95555; Q1MTM8; Q5W129; Q6P2G1; Q9H0P3; Q9H548; Q9NQ68; Q9NQN6; A9Z1Y1
• Molecular Weight: 62,824 Da
• NCBI Official Full Name: dynamin-3 isoform b
• NCBI Official Synonym Full Names: dynamin 3
• NCBI Official Symbol: DNM3
• NCBI Official Synonym Symbols: Dyna III
• NCBI Protein Information: dynamin-3; T-dynamin; dynamin, testicular; dynamin family member
• UniProt Protein Name: Dynamin-3
• Protein Family: Dynamin
• UniProt Gene Name: DNM3
• UniProt Synonym Gene Names: KIAA0820
• UniProt Entry Name: DYN3_HUMAN

NCBI Description

This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Description

DYN3: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within dendritic spine tips of the postsynaptic compartment and interacts with mGluR5 and Homer. May play a role in dendritic spine morphogenesis and remodeling.

Protein type: Mitochondrial; Vesicle; Microtubule-binding; Hydrolase; Motility/polarity/chemotaxis; EC 3.6.5.5; Motor

Chromosomal Location of Human Ortholog: 1q24.3

Cellular Component: microtubule; mitochondrion; perinuclear region of cytoplasm; postsynaptic density; dendritic spine

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: filopodium formation; synaptogenesis; metabolic process; endocytosis