Immunohistochemistry (IHC)
(Anti-ZFYVE26 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Rabbit SPG15 / ZFYVE26 Polyclonal Antibody | anti-SPG15 antibody
Rabbit Polyclonal to Human SPG15 / ZFYVE26
Immunohistochemistry (IHC)
(Anti-ZFYVE26 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunohistochemistry (IHC)
(Anti-ZFYVE26 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunofluorescence (IF)
(Immunofluorescence of SPG15 in Mouse Heart cells with SPG15 antibody at 20 ug/ml.)
Immunofluorescence (IF)
(Immunofluorescence of SPG15 in Mouse Heart cells with SPG15 antibody at 20 ug/ml.)
Western Blot (WB)
(Western blot of SPG15 in rat heart tissue lysate with SPG15 antibody at (A) 0.5 and (B) 1 ug/ml.)
Western Blot (WB)
(Western blot of SPG15 in rat heart tissue lysate with SPG15 antibody at (A) 0.5 and (B) 1 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Uniprot Description
ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 14q24.1
Cellular Component: centrosome; lysosomal membrane; midbody
Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding
Biological Process: cytokinesis; double-strand break repair via homologous recombination
Disease: Spastic Paraplegia 15, Autosomal Recessive
Research Articles on SPG15
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Product Notes
The SPG15 zfyve26 (Catalog #AAA244784) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human SPG15 / ZFYVE26 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SPG15 / ZFYVE26 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA). ELISA, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml). Researchers should empirically determine the suitability of the SPG15 zfyve26 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPG15 / ZFYVE26, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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