Rabbit anti-Human FAP-1 / PTPN13 Polyclonal Antibody | anti-FAP-1 antibody

Rabbit Polyclonal to Human FAP-1 / PTPN13

Cat. Num. AAA242520

• Gene Names: PTPN13; PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: FAP-1 / PTPN13; Polyclonal Antibody; Rabbit Polyclonal to Human FAP-1 / PTPN13; Anti-FAP-1 / PTPN13 Antibody (aa2290-2491) IHC-plus; PTPN13; FAP-1; HPTP1E; HPTPE1; Fas associated phosphatase 1; Phosphatase rip; PTP-BAS; PTP-E1; PTP-BL; PTP1E; PTPLE; PNP1; PTPL1; Human FAP-1; anti-FAP-1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 10 mM PBS, pH 7.4, BSA, sodium azide.
• Sequence Length: 2466

• Applicable Applications for anti-FAP-1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Recombinant protein encoding aa 2290-2491 of human FAP-1.
• Immunogen Type: Recombinant protein
• Immunogen: FAP-1 / PTPN13 antibody was raised against recombinant protein encoding aa 2290-2491 of human FAP-1.
• Antigen Modification: aa2290-2491
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-PTPN13 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC)

(Anti-PTPN13 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Related Product Information for anti-FAP-1 antibody

Fas-associated phosphatase-1 (FAP-1), a NT7 non-receptor protein tyrosine phosphatase, is comprised of a N-terminal FERM domain, five PDZ domains, and a C-terminal tyrosine phosphatase domain. The protein has been shown to bind the cytosolic tail of Fas (Apo1, CD95) and regulate Fas-induced apoptosis. Human tumor cell lines become resistant to Fas-mediated apoptosis when transfected with FAP-1, indicating that FAP-1 functions as a negative regulator in Fas-mediated death signaling.

Product Categories/Family for anti-FAP-1 antibody

Family: Protein Phosphatase; Subfamily: NT7

NCBI and Uniprot Product Information

• NCBI GI #: 5453992
• NCBI GeneID: 5783
• NCBI Accession #: NP_006255.1
• NCBI GenBank Nucleotide #: NM_006264.2
• UniProt Accession #: Q12923; Q15159; Q15263; Q15264; Q15265; Q15674; Q16826; Q8IWH7; Q9NYN9; Q9UDA8; B2RTR0
• Molecular Weight: 277,508 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 13 isoform 2
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
• NCBI Official Symbol: PTPN13
• NCBI Official Synonym Symbols: PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 13; hPTPE1; protein-tyrosine phosphatase 1E; protein-tyrosine phosphatase PTPL1; fas-associated protein-tyrosine phosphatase 1
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 13
• UniProt Gene Name: PTPN13
• UniProt Synonym Gene Names: PNP1; PTP1E; PTPL1; FAP-1; PTP-E1; hPTPE1
• UniProt Entry Name: PTN13_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

Uniprot Description

PTPN13: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21.3

Cellular Component: neuron projection; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: regulation of phosphoinositide 3-kinase cascade; protein amino acid dephosphorylation