Chicken anti-Human Protein Tyrosine Phosphatase, Non-receptor Type 13, Isoform 2 Polyclonal Antibody | anti-PTPN13 antibody

Protein Tyrosine Phosphatase, Non-receptor Type 13, Isoform 2 (PNP1, PTPN13, Protein Tyrosine Phosphatase 1E, Protein Tyrosine Phosphatase PTPL1, APO-1/CD95-associated Phosphatase, Fas-associated Protein Tyrosine Phosphatase 1)

Cat. Num. AAA624648

• Gene Names: PTPN13; PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Protein Tyrosine Phosphatase; Non-receptor Type 13; Isoform 2; Polyclonal Antibody; Isoform 2 (PNP1; PTPN13; Protein Tyrosine Phosphatase 1E; Protein Tyrosine Phosphatase PTPL1; APO-1/CD95-associated Phosphatase; Fas-associated Protein Tyrosine Phosphatase 1); Anti -Protein Tyrosine Phosphatase; anti-PTPN13 antibody

• Host: Chicken
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgY
• Specificity: Recognizes human Protein Tyrosine Phosphatase, Non-receptor Type 13, Isoform 2.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.

• Applicable Applications for anti-PTPN13 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:1000-1:2000
• Immunogen: Synthetic peptide corresponding to aa212-399
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.)

Related Product Information for anti-PTPN13 antibody

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.

Product Categories/Family for anti-PTPN13 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 62087388
• NCBI GeneID: 5783
• UniProt Accession #: Q12923; Q15159; Q15263; Q15264; Q15265; Q15674; Q16826; Q8IWH7; Q9NYN9; Q9UDA8; B2RTR0
• Molecular Weight: 276,906 Da
• NCBI Official Full Name: protein tyrosine phosphatase, non-receptor type 13 isoform 2 variant
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
• NCBI Official Symbol: PTPN13
• NCBI Official Synonym Symbols: PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 13; hPTPE1; protein-tyrosine phosphatase 1E; protein-tyrosine phosphatase PTPL1; fas-associated protein-tyrosine phosphatase 1
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 13
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN13
• UniProt Synonym Gene Names: PNP1; PTP1E; PTPL1; FAP-1; PTP-E1; hPTPE1
• UniProt Entry Name: PTN13_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

Uniprot Description

PTPN13: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 4q21.3

Cellular Component: neuron projection; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: regulation of phosphoinositide 3-kinase cascade; protein amino acid dephosphorylation