Goat anti-Human ABCB9 Polyclonal Antibody | anti-ABCB9 antibody

Goat Polyclonal to Human ABCB9

Cat. Num. AAA242197

• Gene Names: ABCB9; TAPL; EST122234
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: ABCB9; Polyclonal Antibody; Goat Polyclonal to Human ABCB9; Anti-ABCB9 Antibody (C-Terminus) IHC-plus; ABC transporter 9 protein; EST122234; HABCB9; TAP-like ABC transporter; TAPL; KIAA1520; TAP-like protein; Human ABCB9; anti-ABCB9 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human ABCB9. This antibody is expected to recognise both human isoforms of this protein (as represented by NP_062570.1, NP_062571.1and NP_982269.1). Variants (NP_062571.1; NP_982269.1) encode the same isoform.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 766

• Applicable Applications for anti-ABCB9 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:64000), IHC-P (3.75 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-GHNEPVANGSHKA from the C-terminus of human ABCB9 (NP_062570.1; NP_062571.1; NP_982269.1). Percent identity with other species by BLAST analysis: Human (100%), Gibbon (85%), Monkey (85%), Marmoset (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: ABCB9 antibody was raised against synthetic peptide C-GHNEPVANGSHKA from the C-terminus of human ABCB9 (NP_062570.1; NP_062571.1; NP_982269.1). Percent identity with other species by BLAST analysis: Human (100%), Gibbon (85%), Monkey (85%), Marmoset (85%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ABCB9 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.)

Product Categories/Family for anti-ABCB9 antibody

Family: Transporter; Subfamily: ATP-binding cassette - ABCB/MDR

NCBI and Uniprot Product Information

• NCBI GI #: 9955966
• NCBI GeneID: 23457
• NCBI Accession #: NP_062571.1
• NCBI GenBank Nucleotide #: NM_019625.3
• UniProt Accession #: Q9NP78; Q5W9G7; Q769F3; Q769F4; Q96AB1; Q9P208; B4E2J0
• Molecular Weight: 77,470 Da
• NCBI Official Full Name: ATP-binding cassette sub-family B member 9 isoform 1
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family B (MDR/TAP), member 9
• NCBI Official Symbol: ABCB9
• NCBI Official Synonym Symbols: TAPL; EST122234
• NCBI Protein Information: ATP-binding cassette sub-family B member 9; TAP-like protein; ABC transporter 9 protein
• UniProt Protein Name: ATP-binding cassette sub-family B member 9
• Protein Family: ABC transporter B family
• UniProt Gene Name: ABCB9
• UniProt Synonym Gene Names: KIAA1520; ABC transporter 9 protein; hABCB9; TAPL
• UniProt Entry Name: ABCB9_HUMAN

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]

Uniprot Description

ABCB9: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, ABC family; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: lysosomal membrane; lysosome; endoplasmic reticulum; early endosome; integral to membrane; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; protein homodimerization activity; substrate-specific transmembrane transporter activity; ATP binding; peptide-transporting ATPase activity

Biological Process: peptide transport; protein transport; antigen processing and presentation of peptide antigen via MHC class I; metabolic process; transmembrane transport