Rabbit anti-Human TOSO / FAIM3 Polyclonal Antibody | anti-TOSO antibody

Rabbit Polyclonal to Human TOSO / FAIM3

Cat. Num. AAA241269

• Gene Names: FAIM3; FCMR; TOSO
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: TOSO / FAIM3; Polyclonal Antibody; Rabbit Polyclonal to Human TOSO / FAIM3; Anti-TOSO / FAIM3 Antibody (C-Terminus) IHC-plus; FAIM3; FCMR; Immunoglobulin mu Fc receptor; TOSO; Fc mu receptor; IgM Fc receptor; Human TOSO; anti-TOSO antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: 13 amino acid peptide from near the carboxy terminus of human Toso
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 390

• Applicable Applications for anti-TOSO antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: A 13 amino acid peptide from near the carboxy terminus of human Toso.
• Immunogen Type: Synthetic peptide
• Immunogen: TOSO / FAIM3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human Toso.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-FAIM3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of Toso in human lung tissue lysate with Toso antibody at 1 ug/ml in either the (A) presence, or (B) absence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 4885641
• NCBI GeneID: 9214
• NCBI Accession #: NP_005440.1
• NCBI GenBank Nucleotide #: NM_005449.4
• UniProt Accession #: O60667; A8K7J2; B7Z6Z0; D9MWM3
• Molecular Weight: 33,828 Da
• NCBI Official Full Name: fas apoptotic inhibitory molecule 3 isoform a
• NCBI Official Synonym Full Names: Fas apoptotic inhibitory molecule 3
• NCBI Official Symbol: FAIM3
• NCBI Official Synonym Symbols: FCMR; TOSO
• NCBI Protein Information: fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso
• UniProt Protein Name: Fas apoptotic inhibitory molecule 3
• UniProt Gene Name: FAIM3
• UniProt Synonym Gene Names: TOSO
• UniProt Entry Name: FAIM3_HUMAN

NCBI Description

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

Uniprot Description

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: integral to membrane; extracellular region

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis