Rabbit BCAP31 / BAP31 Polyclonal Antibody | anti-BCAP31 antibody

Rabbit Polyclonal to Human BCAP31 / BAP31

Cat. Num. AAA241251

• Gene Names: BCAP31; CDM; DDCH; BAP31; 6C6-AG; DXS1357E
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: BCAP31 / BAP31; Polyclonal Antibody; Rabbit Polyclonal to Human BCAP31 / BAP31; Anti-BCAP31 / BAP31 Antibody (Internal) IHC-plus; BCAP31; 6C6-AG; BCR-associated protein 31; BAP31; BCR-associated protein Bap31; DXS1357E; p28 Bap31; CDM; p28; Protein CDM; Human BCAP31; anti-BCAP31 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: 17 amino acid peptide from near the center of human BAP31
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 246

• Applicable Applications for anti-BCAP31 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: A 17 amino acid peptide from near the center of human BAP31.
• Immunogen Type: Synthetic peptide
• Immunogen: BCAP31 / BAP31 antibody was raised against a 17 amino acid peptide from near the center of human BAP31.
• Antigen Modification: Internal
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-BCAP31 / BAP31 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-BCAP31 / BAP31 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of BAP31 in rat lung tissue lysate with BAP31 antibody at (A) 0.5, (B) 1 and (C) 2ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 32171186
• NCBI GeneID: 10134
• NCBI Accession #: NP_005736.3
• NCBI GenBank Nucleotide #: NM_005745.7
• UniProt Accession #: P51572; Q13836; Q96CF0; B3KQ79; D3DWV5
• Molecular Weight: 34,752 Da
• NCBI Official Full Name: B-cell receptor-associated protein 31 isoform b
• NCBI Official Synonym Full Names: B-cell receptor-associated protein 31
• NCBI Official Symbol: BCAP31
• NCBI Official Synonym Symbols: CDM; DDCH; BAP31; 6C6-AG; DXS1357E
• NCBI Protein Information: B-cell receptor-associated protein 31; p28 Bap31; BCR-associated protein Bap31; 6C6-AG tumor-associated antigen
• UniProt Protein Name: B-cell receptor-associated protein 31
• Protein Family: B-cell receptor-associated protein
• UniProt Gene Name: BCAP31
• UniProt Synonym Gene Names: BAP31; DXS1357E; BCR-associated protein 31; Bap31
• UniProt Entry Name: BAP31_HUMAN

NCBI Description

This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]

Uniprot Description

BCAP31 iso2: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; clathrin-coated vesicle; membrane; endoplasmic reticulum; integral to plasma membrane; lipid particle; cytosol

Molecular Function: protein binding; MHC class I protein binding; protein complex binding

Biological Process: intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; elevation of cytosolic calcium ion concentration; ER to Golgi vesicle-mediated transport; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of caspase activity; spermatogenesis; cell structure disassembly during apoptosis; elevation of mitochondrial calcium ion concentration

Disease: Deafness, Dystonia, And Cerebral Hypomyelination