Rabbit PAK2 Polyclonal Antibody | anti-PAK2 antibody

Rabbit Polyclonal to Human PAK2

Cat. Num. AAA240387

• Gene Names: PAK2; PAK65; PAKgamma
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: PAK2; Polyclonal Antibody; Rabbit Polyclonal to Human PAK2; Anti-PAK2 Antibody (C-Terminus) IHC-plus; HPAK65; p58; PAK65; PAKgamma; Pak-2; S6/H4 kinase; Gamma-PAK; p21-activated kinase 2; Human PAK2; anti-PAK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: 14 amino acid peptide from near the carboxy terminus of human PAK2
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 524

• Applicable Applications for anti-PAK2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (2.5 ug/ml), WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human PAK2.
• Immunogen Type: Synthetic peptide
• Immunogen: PAK2 antibody was raised against synthetic peptide from human PAK2.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-PAK2 antibody IHC of human endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-PAK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-PAK2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of PAK2 in Mouse Spleen cells with PAK2 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of PAK2 in Jurkat lysate with PAK2 antibody at (A) 0.5 and (B) 1 ug/ml.)

Related Product Information for anti-PAK2 antibody

PAK2, a PAK (STE20) type protein kinase, functions in the regulation of the biochemistry and morphology of the apoptotic cell. The protein is activated in response to a variety of stresses, including DNA damage, hyperosmolarity, addition of sphingosine, serum starvation and contact inhibition. Specifically, PAK2 is activated through proteolytic cleavage by capsase 3 during apoptosis.

Product Categories/Family for anti-PAK2 antibody

Family: Protein Kinase; Subfamily: PAK (STE20)

NCBI and Uniprot Product Information

• NCBI GI #: 32483399
• NCBI GeneID: 5062
• NCBI Accession #: NP_002568.2
• NCBI GenBank Nucleotide #: NM_002577.4
• UniProt Accession #: Q13177; Q13154; Q6ISC3
• Molecular Weight: 58,043 Da
• NCBI Official Full Name: serine/threonine-protein kinase PAK 2
• NCBI Official Synonym Full Names: p21 protein (Cdc42/Rac)-activated kinase 2
• NCBI Official Symbol: PAK2
• NCBI Official Synonym Symbols: PAK65; PAKgamma
• NCBI Protein Information: serine/threonine-protein kinase PAK 2; p58; PAK-2; gamma-PAK; S6/H4 kinase; p21-activated kinase 2; p21 (CDKN1A)-activated kinase 2
• UniProt Protein Name: Serine/threonine-protein kinase PAK 2
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: PAK2
• UniProt Synonym Gene Names: PAK-2; p27; p34
• UniProt Entry Name: PAK2_HUMAN

NCBI Description

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

Uniprot Description

PAK2: a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Protein type: Protein kinase, STE; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKA subfamily

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; protein tyrosine kinase activator activity; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: axon guidance; viral reproduction; apoptosis; protein amino acid autophosphorylation; signal transduction; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of defense response to virus by virus; regulation of apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; regulation of growth; T cell costimulation; innate immune response; negative regulation of protein kinase activity; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; phosphorylation; cell structure disassembly during apoptosis; negative regulation of apoptosis