Rabbit COL4A2/Collagen IV Alpha2 Polyclonal Antibody | anti-COL4A2 antibody

Anti-COL4A2/Collagen IV Alpha2 Antibody (N-Terminus)

Cat. Num. AAA2401775

• Gene Names: COL4A2; ICH; POREN2
• Reactivity: Human; Predicted: Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: COL4A2/Collagen IV Alpha2; Polyclonal Antibody; Anti-COL4A2/Collagen IV Alpha2 Antibody (N-Terminus); Rabbit Polyclonal (IgG) to Human COL4A2/Collagen IV Alpha2; COL4A2; Canstatin; Collagen alpha-2(IV) chain; Collagen; type IV; alpha 2; ICH; POREN2; anti-COL4A2 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of Collagen 4 alpha 2 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.
• Sequence Length: 1712

• Applicable Applications for anti-COL4A2 antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P: 1:100; WB: 1:500-1:1000
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-terminal region of human Collagen 4 alpha 2.
• Conjugation: Unconjugated
• Epitope: N-Terminus
• Preparation and Storage: Store at -20 degree C.; Aliquot to avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Human Skeletal Muscle, Nerve: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (WB)

(Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of Collagen 4 alpha 2 expression in SHSY5Y (A); HEK293T (B); NIH3T3 (C) whole cell lysates.)

Related Product Information for anti-COL4A2 antibody

Type IV collagen is the major structural component of glomerularbasement membranes (GBM), forming a 'chicken-wire' meshwork togetherwith laminins, proteoglycans and entactin/nidogen.Canstatin, a cleavageproduct corresponding to the collagen alpha 2(IV) NC1 domain, possessesboth anti-angiogenic and anti-tumor cell activity. It inhibitsproliferation and migration of endothelial cells, reduces mitochondrialmembrane potential, and induces apoptosis.

Product Categories/Family for anti-COL4A2 antibody

Collagen

NCBI and Uniprot Product Information

• NCBI GI #: 116256354
• NCBI GeneID: 1284
• NCBI Accession #: NP_001837.2
• NCBI GenBank Nucleotide #: NM_001846.3
• UniProt Accession #: P08572; Q14052; Q548C3; Q5VZA9; Q66K23
• Molecular Weight: 167,553 Da
• NCBI Official Full Name: collagen alpha-2(IV) chain preproprotein
• NCBI Official Synonym Full Names: collagen type IV alpha 2 chain
• NCBI Official Symbol: COL4A2
• NCBI Official Synonym Symbols: ICH; POREN2
• NCBI Protein Information: collagen alpha-2(IV) chain
• UniProt Protein Name: Collagen alpha-2(IV) chain
• Protein Family: Collagen
• UniProt Gene Name: COL4A2

NCBI Description

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]

Uniprot Description

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.