Mouse anti-Dog C-REACTIVE PROTEIN Monoclonal Antibody | anti-CRP antibody

MOUSE ANTI DOG C-REACTIVE PROTEIN

Cat. Num. AAA224832

• Gene Names: CRP; PTX1
• Reactivity: Dog
• Applications: ELISA
• Synonyms: C-REACTIVE PROTEIN; Monoclonal Antibody; MOUSE ANTI DOG C-REACTIVE PROTEIN; anti-CRP antibody

• Host: Mouse
• Reactivity: Dog
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: cCRP1
• Specificity: C-REACTIVE PROTEIN
• Form/Format: Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 224

• Applicable Applications for anti-CRP antibody: ELISA (EIA)
• Preparation: Purified IgG prepared by affinity chromatography on Protein A
• Preservative Stabilisers: 0.09% Sodium Azide (NaN3)
• Buffer Solution: Phosphate buffered saline
• Preparation and Storage: Store at +4 degree C. DO NOT FREEZE. This product should be stored undiluted. ; Shelf Life: 18 months from date of despatch

Related Product Information for anti-CRP antibody

Mouse anti Dog C-reactive protein, clone cCRP1, specifically recognizes canine C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver in response to cytokine stimulation. CRP belongs to an evolutionally conserved group of pentamer proteins whose function is the protection of an organism against harmful antigens, including invasive infectious agents from bacteria and viruses, and from pyometra and sepsis. Canine CRP is similar in structure to human CRP, however canine CRP differs in that two of the five subunits that make up CRP in dogs are glycosylated while normally none of the subunits making up human CRP are. As clone cCRP1 is specifically raised against dog, this antibody has an advantage over other antibodies raised against human that show cross reactivity with dog, as these cross reactive antibodies may not recognize the glycosylated subunits.

NCBI and Uniprot Product Information

• NCBI GI #: 55770842
• NCBI GeneID: 1401
• NCBI Accession #: NP_000558.2
• NCBI GenBank Nucleotide #: NM_000567.2
• Molecular Weight: 10,415 Da
• NCBI Official Full Name: C-reactive protein
• NCBI Official Synonym Full Names: C-reactive protein, pentraxin-related
• NCBI Official Symbol: CRP
• NCBI Official Synonym Symbols: PTX1
• NCBI Protein Information: C-reactive protein
• UniProt Protein Name: C-reactive protein
• Protein Family: Cryparin
• UniProt Gene Name: CRP
• UniProt Synonym Gene Names: PTX1
• UniProt Entry Name: CRP_HUMAN

NCBI Description

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Uniprot Description

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular region; extracellular space

Molecular Function: calcium ion binding; choline binding; complement component C1q binding; low-density lipoprotein binding; low-density lipoprotein receptor binding; protein binding; virion binding

Biological Process: acute-phase response; defense response to Gram-positive bacterium; inflammatory response; negative regulation of vasodilation; opsonization; positive regulation of superoxide release