Human Nucleoporin 98Kda ELISA Kit | NUP98 elisa kit

Human Nucleoporin 98Kda ELISA Kit

Cat. Num. AAA22135

• Gene Names: NUP98; ADIR2; NUP96; NUP196
• Reactivity: Human
• Synonyms: Nucleoporin 98Kda; Human Nucleoporin 98Kda ELISA Kit; NUP98 elisa kit

• Reactivity: Human
• Sequence Length: 1726

• Detection Range: 3.12ng/ml-100ng/ml
• Sensitivity: 1.0ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Inter-Assay: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of NUP98 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 56549645
• NCBI GeneID: 4928
• NCBI Accession #: NP_624358.2
• NCBI GenBank Nucleotide #: NM_139132.3
• UniProt Accession #: P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5
• Molecular Weight: 197,579 Da
• NCBI Official Full Name: nuclear pore complex protein Nup98-Nup96 isoform 4
• NCBI Official Synonym Full Names: nucleoporin 98kDa
• NCBI Official Symbol: NUP98
• NCBI Official Synonym Symbols: ADIR2; NUP96; NUP196
• NCBI Protein Information: nuclear pore complex protein Nup98-Nup96; nucleoporin 98kD; GLFG-repeat containing nucleoporin
• UniProt Protein Name: Nuclear pore complex protein Nup98-Nup96
• UniProt Gene Name: NUP98
• UniProt Synonym Gene Names: ADAR2; Nup98; Nup96
• UniProt Entry Name: NUP98_HUMAN

NCBI Description

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]

Uniprot Description

NUP98: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Belongs to the nucleoporin GLFG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Nucleoporin

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: kinetochore; nucleoplasm; nuclear membrane; nuclear pore; nuclear envelope; cytosol; nuclear inclusion body

Molecular Function: protein binding; structural constituent of nuclear pore; transporter activity; peptide binding

Biological Process: nuclear pore complex assembly; mRNA transport; viral reproduction; protein import into nucleus, docking; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; nucleocytoplasmic transport; pathogenesis; viral infectious cycle; glucose transport; nuclear pore organization and biogenesis; hexose transport; carbohydrate metabolic process; viral transcription; gene expression; mitotic cell cycle; DNA replication; transmembrane transport