Testing Data
(Staining of thrombin activated human peripheral blood platelets with Mouse anti Human CD62E/CD62P: FITC (MBS211116))
Mouse CD62E/CD62P Monoclonal Antibody | anti-CD62E/CD62P antibody
MOUSE ANTI HUMAN CD62E/CD62P
Purified IgG - liquid
Immunohistology - Frozen: Minimum Dilution: 1ug/ml; Maximum Dilution: 10ug/ml; Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections.
ELISA: Maximum Dilution: 10ug/ml
Flow Cytometry: Maximum Dilution: 10ug/ml
Western Blotting: Application Note: Clone 1.2B6 recognizes human CD62E/CD62P only under non-reducing conditions.
Preparation
Histology Positive Control Tissue
Shelf Life: 18 months from date of despatch.
Testing Data
(Staining of thrombin activated human peripheral blood platelets with Mouse anti Human CD62E/CD62P: FITC (MBS211116))
Testing Data
(Staining of thrombin activated human peripheral blood platelets with Mouse anti Human CD62E/CD62P: FITC (MBS211116))
Testing Data
(Staining of thrombin activated human peripheral blood platelets with Mouse anti Human CD62E/CD62P (MBS213185))
Testing Data
(Staining of thrombin activated human peripheral blood platelets with Mouse anti Human CD62E/CD62P (MBS213185))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Uniprot Description
SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q22-q25
Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; plasma membrane; integral to membrane; coated pit; caveola; lipid raft
Molecular Function: protein binding; phospholipase binding; transmembrane receptor activity; sialic acid binding
Biological Process: heterophilic cell adhesion; leukocyte adhesion; phospholipase C activation; positive regulation of leukocyte migration; regulation of inflammatory response; positive regulation of receptor internalization; actin filament-based process; calcium-mediated signaling; response to lipopolysaccharide; leukocyte tethering or rolling; inflammatory response; blood coagulation; leukocyte migration; leukocyte migration during inflammatory response
Disease: Hypertension, Essential
Research Articles on CD62E/CD62P
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Product Notes
The CD62E/CD62P sele (Catalog #AAA216652) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD62E/CD62P can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen*, ELISA (EIA), Flow cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)*. Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Immunohistology - Frozen: Minimum Dilution: 1ug/ml; Maximum Dilution: 10ug/ml; Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections. ELISA: Maximum Dilution: 10ug/ml Flow Cytometry: Maximum Dilution: 10ug/ml Western Blotting: Application Note: Clone 1.2B6 recognizes human CD62E/CD62P only under non-reducing conditions. Researchers should empirically determine the suitability of the CD62E/CD62P sele for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD62E/CD62P, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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