Suppressor Of Zeste 12 Homolog (SUZ12) Recombinant Protein | SUZ12 recombinant protein

Recombinant Suppressor Of Zeste 12 Homolog (SUZ12)

Cat. Num. AAA2124691

• Gene Names: SUZ12; CHET9; JJAZ1
• Applications: SDS-Page, Western Blot
• Purity: >97%
• Synonyms: Suppressor Of Zeste 12 Homolog (SUZ12); Recombinant Suppressor Of Zeste 12 Homolog (SUZ12); Suppressor Of Zeste 12 Homolog; CHET9; JJAZ1; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; SUZ12 recombinant protein

• Host: E Coli
• Purity/Purification: >97%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence: Leu448~Phe639

• Applicable Applications for SUZ12 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Usage: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for SUZ12 recombinant protein

Signal transduction; Recombinant proteins/RP

NCBI and Uniprot Product Information

• NCBI GI #: 119600664
• NCBI GeneID: 23512
• UniProt Accession #: Q15022; Q96BD9
• Molecular Weight: 83,055 Da
• NCBI Official Full Name: suppressor of zeste 12 homolog (Drosophila)
• NCBI Official Synonym Full Names: SUZ12 polycomb repressive complex 2 subunit
• NCBI Official Symbol: SUZ12
• NCBI Official Synonym Symbols: CHET9; JJAZ1
• NCBI Protein Information: polycomb protein SUZ12; chET 9 protein; joined to JAZF1 protein; suppressor of zeste 12 homolog; suppressor of zeste 12 protein homolog; chromatin precipitated E2F target 9 protein
• UniProt Protein Name: Polycomb protein SUZ12
• Protein Family: Polycomb protein
• UniProt Gene Name: SUZ12
• UniProt Synonym Gene Names: CHET9; JJAZ1; KIAA0160; ChET 9 protein
• UniProt Entry Name: SUZ12_HUMAN

NCBI Description

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

Uniprot Description

SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: Oncoprotein; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; sex chromatin; ESC/E(Z) complex; nucleolus; nucleus

Molecular Function: histone methyltransferase activity; protein binding; sequence-specific DNA binding; RNA binding; metal ion binding; chromatin binding; methylated histone residue binding

Biological Process: histone methylation; negative regulation of cell differentiation; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; histone ubiquitination; positive regulation of cell proliferation; gene expression; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic