Clathrin, Heavy Polypeptide Recombinant Protein | CLTC recombinant protein

Recombinant Clathrin, Heavy Polypeptide (CLTC)

Cat. Num. AAA2123588

• Gene Names: CLTC; Hc; CHC; CHC17; MRD56; CLH-17; CLTCL2
• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: Clathrin; Heavy Polypeptide; Recombinant Clathrin; Heavy Polypeptide (CLTC); CLTCL2; Hc; CLH17; Heavy Polypeptide-Like 2; Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; CLTC recombinant protein

• Host: E Coli
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Ala2~Pro242
• Sequence Length: 1675

• Applicable Applications for CLTC recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His and GST Tag
• Subcellular Location: Coated Pit, Cytoplasmic vesicle, Membrane
• Isoelectric Point: 8.3
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for CLTC recombinant protein

Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4758012
• NCBI GeneID: 1213
• NCBI Accession #: NP_004850.1
• NCBI GenBank Nucleotide #: NP_004850.1
• UniProt Accession #: Q00610
• Molecular Weight: Predicted Molecular Mass: 56.7kDa; Accurate Molecular Mass: 57kDa
• NCBI Official Full Name: clathrin heavy chain 1 isoform 1
• NCBI Official Synonym Full Names: clathrin heavy chain
• NCBI Official Symbol: CLTC
• NCBI Official Synonym Symbols: Hc; CHC; CHC17; MRD56; CLH-17; CLTCL2
• NCBI Protein Information: clathrin heavy chain 1
• UniProt Protein Name: Clathrin heavy chain 1
• Protein Family: Clathrin
• UniProt Gene Name: CLTC
• UniProt Synonym Gene Names: CLH17; CLTCL2; KIAA0034; CLH-17

NCBI Description

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

Uniprot Description

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872).