Rat CD117 Monoclonal Antibody | anti-CD117 antibody
RAT ANTI MOUSE CD117
Purified IgG - liquid
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/200
Preparation
Fusion Partners
Shelf Life: 18 months from date of despatch.
NCBI and Uniprot Product Information
NCBI Description
The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Kit: a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes.
Protein type: Membrane protein, integral; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; TK group; PDGFR family
Cellular Component: extracellular space; internal side of plasma membrane; mast cell granule; cell surface; membrane; cytoplasm; integral to membrane; acrosome; plasma membrane; intercellular junction; intracellular; external side of plasma membrane
Molecular Function: protein homodimerization activity; protease binding; metal ion binding; nucleotide binding; stem cell factor receptor activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; protein-tyrosine kinase activity; cytokine binding; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: activation of MAPK activity; somatic stem cell maintenance; germ cell programmed cell death; positive regulation of JAK-STAT cascade; lymphoid progenitor cell differentiation; positive regulation of long-term neuronal synaptic plasticity; protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; germ cell development; positive regulation of MAP kinase activity; regulation of cell shape; epithelial cell proliferation; germ cell migration; somatic stem cell division; erythrocyte differentiation; T cell differentiation; mast cell chemotaxis; embryonic hemopoiesis; stem cell differentiation; detection of mechanical stimulus involved in sensory perception of sound; positive regulation of tyrosine phosphorylation of Stat1 protein; glycosphingolipid metabolic process; immature B cell differentiation; positive regulation of transcription factor activity; regulation of pigmentation during development; mast cell cytokine production; transmembrane receptor protein tyrosine kinase signaling pathway; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; pigmentation during development; chemotaxis; response to radiation; ovarian follicle development; positive regulation of MAPKKK cascade; myeloid progenitor cell differentiation; melanocyte differentiation; positive regulation of cell proliferation; negative regulation of programmed cell death; visual learning; hemopoiesis; cell differentiation; inflammatory response; positive regulation of Notch signaling pathway; lamellipodium biogenesis; dendritic cell cytokine production; cytokine and chemokine mediated signaling pathway; mast cell degranulation; positive regulation of pseudopodium formation; pigmentation; gut development; positive regulation of tyrosine phosphorylation of Stat5 protein; actin cytoskeleton reorganization; myeloid leukocyte differentiation; spermatogenesis; phosphorylation; spermatid development; positive regulation of cell migration
Research Articles on CD117
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Product Notes
The CD117 kit (Catalog #AAA212115) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD117 can be used in a range of immunoassay formats including, but not limited to, Flow cytometry (FC/FACS). Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/200. Researchers should empirically determine the suitability of the CD117 kit for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD117, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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