Mouse Mast/stem cell growth factor receptor Kit ELISA Kit | Kit elisa kit

Mouse Mast/stem cell growth factor receptor Kit ELISA Kit

Cat. Num. AAA2883140

• Gene Names: Kit; W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3
• Reactivity: Mouse
• Synonyms: Mast/stem cell growth factor receptor Kit; Mouse Mast/stem cell growth factor receptor Kit ELISA Kit; SCFR; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; Kit; Sl; 2.7.10.1; CD117; Kit elisa kit

• Reactivity: Mouse
• Sequence Length: 979

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.083 ng/mL
• Intra-Assay CV: <=6.3%
• Inter-Assay CV: <=10.8%
• Recovery: 107%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 170650721
• NCBI GeneID: 16590
• NCBI Accession #: NP_001116205.1
• NCBI GenBank Nucleotide #: NM_001122733.1
• UniProt Accession #: P05532; Q61415; Q61416; Q61417; Q6LEE9; Q6QJB7; Q6QJB8; Q7TS86; Q8C8K9
• Molecular Weight: 22,814 Da
• NCBI Official Full Name: mast/stem cell growth factor receptor Kit isoform 1
• NCBI Official Synonym Full Names: kit oncogene
• NCBI Official Symbol: Kit
• NCBI Official Synonym Symbols: W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3
• NCBI Protein Information: mast/stem cell growth factor receptor Kit
• UniProt Protein Name: Mast/stem cell growth factor receptor Kit
• Protein Family: Mast/stem cell growth factor receptor
• UniProt Gene Name: Kit
• UniProt Synonym Gene Names: Sl; SCFR
• UniProt Entry Name: KIT_MOUSE

NCBI Description

The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Kit: a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes.

Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; Oncoprotein; Kinase, protein; TK group; PDGFR family

Cellular Component: acrosome; cell surface; cytoplasm; external side of plasma membrane; extracellular space; integral to membrane; intercellular junction; internal side of plasma membrane; mast cell granule; membrane; plasma membrane

Molecular Function: ATP binding; cytokine binding; kinase activity; metal ion binding; nucleotide binding; protease binding; protein binding; protein homodimerization activity; protein kinase activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; stem cell factor receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: actin cytoskeleton reorganization; activation of MAPK activity; cell differentiation; chemotaxis; cytokine and chemokine mediated signaling pathway; dendritic cell cytokine production; detection of mechanical stimulus involved in sensory perception of sound; embryonic hemopoiesis; epithelial cell proliferation; erythrocyte differentiation; germ cell development; germ cell migration; germ cell programmed cell death; glycosphingolipid metabolic process; gut development; hemopoiesis; immature B cell differentiation; inflammatory response; lamellipodium biogenesis; lymphoid progenitor cell differentiation; mast cell chemotaxis; mast cell cytokine production; mast cell degranulation; melanocyte differentiation; myeloid leukocyte differentiation; myeloid progenitor cell differentiation; negative regulation of programmed cell death; ovarian follicle development; peptidyl-tyrosine phosphorylation; phosphorylation; pigmentation; pigmentation during development; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of long-term neuronal synaptic plasticity; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of Notch signaling pathway; positive regulation of pseudopodium formation; positive regulation of transcription factor activity; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell shape; regulation of pigmentation during development; response to radiation; somatic stem cell division; somatic stem cell maintenance; spermatid development; spermatogenesis; stem cell differentiation; T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; visual learning