Human Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Antibody Pair Kit | PDK1 antibody pair kit

Human Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Antibody Pair Kit (with Standard)

Reactivity

Human

Applications

ELISA, ELISA

Synonyms

Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1); Human Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Antibody Pair Kit (with Standard); [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1; mitochondrial; PDK1 antibody pair kit

Ordering
Cat. Num. AAA2101978 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human

Applicable Applications for PDK1 antibody pair kit

ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex

Samples

Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids

Detection Range

31.2-2000ng/mL

Standard

Recombinant PDK1 (Lyophilized, 1 vial-10ug)

Capture Antibody

Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)

Detection Antibody

Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)

Producte Usage

Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.

Antibody Support Pack

Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685

Product Categories/Family for PDK1 antibody pair kit

Enzyme & Kinase

NCBI and Uniprot Product Information

NCBI GI #

59709473

NCBI GeneID

116551

NCBI Accession #

NP_446278.2

NCBI GenBank Nucleotide #

NM_053826.2

UniProt Accession #

Q63065

Molecular Weight

49,081 Da

NCBI Official Full Name

pyruvate dehydrogenase kinase, isozyme 1

NCBI Official Synonym Full Names

pyruvate dehydrogenase kinase 1

NCBI Official Symbol

Pdk1

NCBI Protein Information

pyruvate dehydrogenase kinase, isozyme 1

UniProt Protein Name

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Protein Family

[Pyruvate dehydrogenase

UniProt Gene Name

Pdk1

UniProt Synonym Gene Names

Pdh; PDH kinase 1

NCBI Description

catalyzes the phosphorylation and inactivation of the pyruvate dehydrogenase complex [RGD, Feb 2006]

Uniprot Description

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Research Articles on PDK1

1. The expression of three well-defined downstream targets of hypoxia inducible factor 1 alpha subunit (HIF-1alpha), pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDHA) and vascular endothelial growth factor (VEGF), were up-regulated in hippocampus after 28 days of simulated microgravity exposure.

Similar Products

Product Notes

The Human PDK1 pdk1 (Catalog #AAA2101978) is an Antibody Pair Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2101978 Antibody Pair Kit recognizes Human PDK1. AAA Biotech's Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex. Researchers should empirically determine the suitability of the PDK1 pdk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1), Antibody Pair Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...