Western Blot (WB)
(PRTN3 rabbit polyclonal antibody. Western Blot analysis of PRTN3 expression in mouse brain.)
Rabbit anti-Human, Mouse Proteinase 3 Polyclonal Antibody | anti-PR3 antibody
Proteinase 3 (Proteinase-3, PR3, PR-3, PRTN3, ACPA, Azurophil Granule Protein 7, AGP7, cANCA, c-ANCA Antigen, EC 3.4.21.76, Leukocyte Proteinase 3, MBT, Myeloblastin, MBN, Neutrophil Proteinase 4, NP4, NP-4, p29, Wegener Autoantigen) (PE)
Gene Names
PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
Proteinase 3; Polyclonal Antibody; Proteinase 3 (Proteinase-3; PR3; PR-3; PRTN3; ACPA; Azurophil Granule Protein 7; AGP7; cANCA; c-ANCA Antigen; EC 3.4.21.76; Leukocyte Proteinase 3; MBT; Myeloblastin; MBN; Neutrophil Proteinase 4; NP4; NP-4; p29; Wegener Autoantigen) (PE); anti-PR3 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human PRTN3. Species Crossreactivity: mouse.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Sequence Length
860
Applicable Applications for anti-PR3 antibody
Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Full length human PRTN3, aa1-256 (AAH96184.1).
Immunogen Sequence
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDILLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
Conjugate
PE
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(PRTN3 rabbit polyclonal antibody. Western Blot analysis of PRTN3 expression in mouse brain.)
Western Blot (WB)
(PRTN3 rabbit polyclonal antibody. Western Blot analysis of PRTN3 expression in mouse brain.)
Western Blot (WB)
(Western Blot analysis of PRTN3 expression in transfected 293T cell line by PRTN3 polyclonal antibody. Lane 1: PRTN3 transfected lysate (27.8kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of PRTN3 expression in transfected 293T cell line by PRTN3 polyclonal antibody. Lane 1: PRTN3 transfected lysate (27.8kD). Lane 2: Non-transfected lysate.)
Related Product Information for anti-PR3 antibody
Proteinase 3 (PRTN3; also PR3/leukocyte, Myeloblastin and NP-4) is a 32-33kD member of the peptidase S1 family of enzymes. It is expressed by monocytes and neutrophils, the latter of which either secretes it, sequesters it in azurophilic granules, or expresses it on the cell surface. When secreted, it acts on HK and activates the kinin pathway. In azurophilic granules, it aids in the digestion of phagocytosed material. On the cell surface, it likely acts on ECM. Human PRTN3 proprecursor is 231aa in length. It contains an Ala26Glu27 propeptide that is removed during maturation, a 221aa mature enzyme (aa28-248), and an eight aa C-terminal propeptide (aa249-256). Within the cell, a 35kD immature form exists; on the cell surface, both constitutively inactive, and induced active forms may be found, often in a noncovalent association with CD177/NB1. Over aa26-249, human PRTN3 shares 68% aa identity with mouse PRTN3.
Product Categories/Family for anti-PR3 antibody
NCBI and Uniprot Product Information
Research Articles on PR3
Similar Products
Product Notes
The PR3 (Catalog #AAA6390955) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Proteinase 3 (Proteinase-3, PR3, PR-3, PRTN3, ACPA, Azurophil Granule Protein 7, AGP7, cANCA, c-ANCA Antigen, EC 3.4.21.76, Leukocyte Proteinase 3, MBT, Myeloblastin, MBN, Neutrophil Proteinase 4, NP4, NP-4, p29, Wegener Autoantigen) (PE) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Proteinase 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PR3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Proteinase 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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