Rabbit anti-Human SNAP Associated Protein (SNAPAP) Polyclonal Antibody | anti-SNAPAP antibody
Biotin-Linked Polyclonal Antibody to SNAP Associated Protein (SNAPAP)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Uniprot Description
SNAPIN: a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. Phosphorylation by PKA modulates its interaction with the SNARE complex.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: axon cytoplasm; BORC complex; cell junction; Golgi membrane; lysosomal membrane; perinuclear region of cytoplasm; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane
Molecular Function: protein binding; SNARE binding
Biological Process: anterograde axon cargo transport; anterograde synaptic vesicle transport; cellular protein complex localization; endosome to lysosome transport; intracellular protein transport; late endosome to lysosome transport; lysosomal lumen acidification; lysosome localization; melanosome organization; negative regulation of neuron projection development; neuron projection development; neurotransmitter secretion; protein maturation; regulation of protein binding; retrograde axon cargo transport; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic membrane; synaptic vesicle maturation; synaptic vesicle transport; terminal button organization; viral process
Research Articles on SNAPAP
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Product Notes
The SNAPAP snapin (Catalog #AAA2096364) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to SNAP Associated Protein (SNAPAP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SNAP Associated Protein (SNAPAP) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the SNAPAP snapin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNAP Associated Protein (SNAPAP), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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