Rabbit anti-Human Peptidylglycine Alpha Amidating Monooxygenase (PAM) Polyclonal Antibody | anti-PAM antibody
Biotin-Linked Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Description
PAM: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle
Chromosomal Location of Human Ortholog: 5q21.1
Cellular Component: cell surface; extracellular exosome; integral component of membrane; membrane; neuron projection; perikaryon; perinuclear region of cytoplasm; plasma membrane; secretory granule membrane; trans-Golgi network
Molecular Function: calcium ion binding; copper ion binding; L-ascorbic acid binding; peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; protein binding; protein kinase binding; zinc ion binding
Biological Process: central nervous system development; heart development; lactation; limb development; long-chain fatty acid metabolic process; maternal process involved in female pregnancy; odontogenesis; ovulation cycle process; peptide amidation; protein amidation; protein homooligomerization; regulation of actin cytoskeleton organization; regulation of protein secretion; regulation of transcription from RNA polymerase II promoter; response to copper ion; response to drug; response to estradiol; response to glucocorticoid stimulus; response to hypoxia; response to pH; toxin metabolic process
Research Articles on PAM
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Product Notes
The PAM pam (Catalog #AAA2094841) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Peptidylglycine Alpha Amidating Monooxygenase (PAM) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Peptidylglycine Alpha Amidating Monooxygenase (PAM) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PAM pam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Peptidylglycine Alpha Amidating Monooxygenase (PAM), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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