Rabbit anti-Mouse Calcium Sensing Receptor (CASR) Polyclonal Antibody | anti-CASR antibody
Biotin-Linked Polyclonal Antibody to Calcium Sensing Receptor (CASR)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
Uniprot Description
CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3q13.33-q21.1
Cellular Component: apical plasma membrane; axon; axon terminus; basolateral plasma membrane; cell soma; cell surface; cytoplasm; integral component of plasma membrane; nucleus; plasma membrane
Molecular Function: amino acid binding; calcium ion binding; drug binding; G-protein coupled receptor activity; integrin binding; ion channel binding; magnesium ion binding; phosphoinositide phospholipase C activity; polyamine binding; protein binding; protein homodimerization activity; protein kinase binding
Biological Process: anatomical structure morphogenesis; apoptosis; branching morphogenesis of a tube; cellular calcium ion homeostasis; cellular response to glucose stimulus; cellular response to hypoxia; cellular response to low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to vitamin D; chemosensory behavior; detection of calcium ion; G-protein coupled receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; JNK cascade; ossification; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of ATPase activity; positive regulation of calcium ion import; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of insulin secretion; positive regulation of positive chemotaxis; positive regulation of vasoconstriction; response to fibroblast growth factor; vasodilation
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I
Research Articles on CASR
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Product Notes
The CASR casr (Catalog #AAA2094493) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Calcium Sensing Receptor (CASR) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Calcium Sensing Receptor (CASR) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the CASR casr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcium Sensing Receptor (CASR), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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