Mouse anti-Human Mucin 2 (MUC2) Monoclonal Antibody | anti-MUC2 antibody

Monoclonal Antibody to Mucin 2 (MUC2)

Cat. Num. AAA2090663

• Gene Names: MUC2; MLP; SMUC; MUC-2
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation
• Purity: Protein A + Protein G affinity chromatography
• Synonyms: Mucin 2 (MUC2); Monoclonal Antibody; Monoclonal Antibody to Mucin 2 (MUC2); MLP; SMUC; Oligomeric Mucus/Gel-Forming; Mucin 2; Intestinal/Tracheal; anti-MUC2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1 Kappa
• Clone Number: C1
• Specificity: The antibody is a mouse monoclonal antibody raised against MUC2. It has been selected for its ability to recognize MUC2 in immunohistochemical staining and western blotting.
• Purity/Purification: Protein A + Protein G affinity chromatography
• Form/Format: Liquid
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 5179

• Applicable Applications for anti-MUC2 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
• Application Notes: Western Blot: 0.5-5ug/mL; Immunohistochemistry: 5-30ug/mL; Immunocytochemistry: 5-30ug/mL
• Immunogen: Recombinant Mucin 2 (MUC2)
• Cross Reactivity: Human
• Buffer Formulation: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
• Preparation and Storage: Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Western Blot (WB)

(Figure. Western Blot: Sample: Recombinant MUC2, Human)

NCBI and Uniprot Product Information

• NCBI GI #: 2506877
• NCBI GeneID: 4583
• UniProt Accession #: Q02817; Q14878
• Molecular Weight: 540,300 Da
• NCBI Official Full Name: Mucin-2
• NCBI Official Synonym Full Names: mucin 2, oligomeric mucus/gel-forming
• NCBI Official Symbol: MUC2
• NCBI Official Synonym Symbols: MLP; SMUC; MUC-2
• NCBI Protein Information: mucin-2
• UniProt Protein Name: Mucin-2
• Protein Family: Mucin
• UniProt Gene Name: MUC2
• UniProt Synonym Gene Names: SMUC; MUC-2

NCBI Description

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]

Uniprot Description

MUC2: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Protein type: Extracellular matrix; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: Golgi lumen; plasma membrane

Molecular Function: protein binding

Biological Process: maintenance of gastrointestinal epithelium; O-glycan processing; stimulatory C-type lectin receptor signaling pathway