ATP Binding Cassette Transporter A7 (ABCA7) Recombinant Protein | ABCA7 recombinant protein

Recombinant ATP Binding Cassette Transporter A7 (ABCA7)

Cat. Num. AAA2086832

• Gene Names: ABCA7; AD9; ABCX; ABCA-SSN
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: ATP Binding Cassette Transporter A7 (ABCA7); Recombinant ATP Binding Cassette Transporter A7 (ABCA7); ABC-A7; ABCA-SSN; ABCX; Autoantigen SS-N; Macrophage ABC transporter; ABCA7 recombinant protein

• Host: E Coli
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 2146

• Applicable Applications for ABCA7 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Fragment: Glu53~Leu249
• Tag: Two N-terminal Tags, His-tag and GST-tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Prokaryotic expression
• Organism Species: Human
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 5.2
• Subcellular Location: Cell Membrane. Multi-pass Membrane Protein. Golgi Apparatus Membrane. Endosome Membrane.
• Usage: Reconstitute in PBS or others.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for ABCA7 recombinant protein

Recombinant Protein

NCBI and Uniprot Product Information

• NCBI GI #: 150417984
• NCBI GeneID: 10347
• NCBI Accession #: NP_061985.2
• NCBI GenBank Nucleotide #: NM_019112.3
• UniProt Accession #: Q8IZY2; Q96S58; Q9BZC4; Q9NR73; Q9UKP8
• Molecular Weight: 51.0kDa
• NCBI Official Full Name: ATP-binding cassette sub-family A member 7
• NCBI Official Synonym Full Names: ATP binding cassette subfamily A member 7
• NCBI Official Symbol: ABCA7
• NCBI Official Synonym Symbols: AD9; ABCX; ABCA-SSN
• NCBI Protein Information: ATP-binding cassette sub-family A member 7
• UniProt Protein Name: ATP-binding cassette sub-family A member 7
• Protein Family: ABC transporter A family
• UniProt Gene Name: ABCA7

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: ATP-binding cassette (ABC) transporter complex; cell junction; cell surface; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; phagocytic cup; plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity

Biological Process: cholesterol efflux; memory; negative regulation of amyloid precursor protein biosynthetic process; peptide cross-linking; phospholipid efflux; phospholipid translocation; positive regulation of phagocytosis; transmembrane transport

Disease: Alzheimer Disease 9, Susceptibility To