Gallus anti-Human Ras Related C3 Botulinum Toxin Substrate 1 (Rac1) Polyclonal Antibody | anti-Rac1 antibody
FITC-Linked Polyclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 1 (Rac1)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
Note: As fluorescence can photo bleach when exposed to light, so the antibody must be protected from light.
NCBI and Uniprot Product Information
Uniprot Description
RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12p11
Cellular Component: actin filament; cell projection; cytoplasm; cytoplasmic vesicle; cytosol; early endosome membrane; extrinsic to plasma membrane; focal adhesion; Golgi membrane; lamellipodium; membrane; nucleus; pericentriolar material; phagocytic cup; plasma membrane; trans-Golgi network
Molecular Function: ATPase binding; enzyme binding; GTP binding; GTP-dependent protein binding; GTPase activity; histone deacetylase binding; protein binding; protein kinase binding; Rab GTPase binding; Rho GDP-dissociation inhibitor binding; thioesterase binding
Biological Process: actin cytoskeleton organization and biogenesis; actin filament organization; actin filament polymerization; auditory receptor cell morphogenesis; axon guidance; bone resorption; cell adhesion; cell migration; cell motility involved in cell locomotion; cell proliferation; cerebral cortex GABAergic interneuron development; cerebral cortex radially oriented cell migration; chemotaxis; cytoskeleton organization and biogenesis; dendrite development; dendrite morphogenesis; embryonic olfactory bulb interneuron precursor migration; endocytosis; engulfment of apoptotic cell; G-protein coupled receptor protein signaling pathway; homeostasis of number of cells within a tissue; hyperosmotic response; intercellular junction assembly and maintenance; lamellipodium biogenesis; localization within membrane; mast cell chemotaxis; negative regulation of interleukin-23 production; neurite morphogenesis; organization of an anatomical structure; phagocytosis, engulfment; positive regulation of actin filament polymerization; positive regulation of DNA replication; positive regulation of focal adhesion formation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; Rac protein signal transduction; regulation of cell migration; regulation of cell morphogenesis; regulation of cell size; regulation of neuron maturation; regulation of neuronal synaptic plasticity; ruffle organization and biogenesis; small GTPase mediated signal transduction; synaptic transmission, GABAergic; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on Rac1
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Product Notes
The Rac1 rac1 (Catalog #AAA2083888) is an Antibody produced from Gallus and is intended for research purposes only. The product is available for immediate purchase. The FITC-Linked Polyclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 1 (Rac1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ras Related C3 Botulinum Toxin Substrate 1 (Rac1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, Immunofluorescence (IF). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the Rac1 rac1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ras Related C3 Botulinum Toxin Substrate 1 (Rac1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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