Rabbit anti-Human V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Polyclonal Antibody | anti-KRAS antibody
APC/CY7-Linked Polyclonal Antibody to V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS)
NCBI and Uniprot Product Information
NCBI Description
oncogene and member of the small GTPase superfamily [RGD, Feb 2006]
Uniprot Description
KRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 4q44
Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; focal adhesion; lipid raft; membrane; mitochondrion; plasma membrane
Molecular Function: GDP binding; GMP binding; GTPase activity; LRR domain binding; protein binding; protein complex binding
Biological Process: actin cytoskeleton organization and biogenesis; activation of NF-kappaB transcription factor; cytokine and chemokine mediated signaling pathway; forebrain astrocyte development; homeostasis of number of cells within a tissue; insulin receptor signaling pathway; liver development; negative regulation of cell differentiation; negative regulation of neuron apoptosis; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; positive regulation of Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of protein stability; regulation of synaptic transmission, GABAergic; response to glucocorticoid stimulus; response to mineralocorticoid stimulus; striated muscle cell differentiation; visual learning
Research Articles on KRAS
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Product Notes
The KRAS kras (Catalog #AAA2080247) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APC/CY7-Linked Polyclonal Antibody to V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the KRAS kras for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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