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SDS-Page

NFATC2 recombinant protein

NFATC2, 396-678aa, Human, His-tag, Baculovirus

Gene Names
NFATC2; NFAT1; NFATP
Applications
SDS-Page
Purity
> 90% by SDS-PAGE
Synonyms
NFATC2; 396-678aa; Human; His-tag; Baculovirus; Nuclear factor of activated T-cells cytoplasmic 2 isoform C; NFAT1; NFATP; NFATC2 recombinant protein
Ordering
For Research Use Only!
Host
Baculovirus
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 40% glycerol, 1mM DTT.
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
Sequence
PLEWPLSSQS GSYELRIEVQ PKPHHRAHYE TEGSRGAVKA PTGGHPVVQL HGYMENKPLG LQIFIGTADE RILKPHAFYQ VHRITGKTVT TTSYEKIVGN TKVLEIPLEP KNNMRATIDC AGILKLRNAD IELRKGETDI GRKNTRVRLV FRVHIPESSG RIVSLQTASN PIECSQRSAH ELPMVERQDT DSCLVYGGQQ MILTGQNFTS ESKVVFTEKT TDGQQIWEME ATVDKDKSQP NMLFVEIPEY RNKHIRTPVK VNFYVINGKR KRSQPQHFTY HPVHHHHHH
Sequence Length
925
Applicable Applications for NFATC2 recombinant protein
SDS-PAGE
Antigen Species
Human
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1ug of protein (determined by LAL method)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

SDS-Page

SDS-Page
Related Product Information for NFATC2 recombinant protein
NFATC2, also known as nuclear factor of activated T-cells cytoplasmic 2 isoform C, is a member of the nuclear factor of activated T cells family. This protein plays a vital role in the course of T helper cell activation, differentiation, and effector function. Although KO of an individual NFAT isoform in T cells leads to rather mild effects, T cells deficient for NFATC1 and 2 completely fail to produce T helper cell effector cytokines, such as the interleukins IL-2 and IL-4 or interferon gamma. Also, it is highly phosphorylated and retained in the cytoplasm. Following T cell receptor (TCR) stimulation, dephosphorylation by calcium-activated calcineurin induces a conformational change of NFATC2 that exposes one or more nuclear localization sequences. Recombinant human NFATC2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Categories/Family for NFATC2 recombinant protein
References
Gabriel CH., et al, (2016) J. Biol. Chem. 291:24172-24187. Ho S., et al, (1994) Adv. Exp. Med. Biol. 365:167-173.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33.1kDa (290aa) 28-40kDa (SDS-PAGE under reducing conditions.)
NCBI Official Full Name
nuclear factor of activated T-cells, cytoplasmic 2 isoform C
NCBI Official Synonym Full Names
nuclear factor of activated T cells 2
NCBI Official Symbol
NFATC2
NCBI Official Synonym Symbols
NFAT1; NFATP
NCBI Protein Information
nuclear factor of activated T-cells, cytoplasmic 2
UniProt Protein Name
Nuclear factor of activated T-cells, cytoplasmic 2
UniProt Gene Name
NFATC2
UniProt Synonym Gene Names
NFAT1; NFATP; NF-ATc2; NFATc2; NF-ATp

NCBI Description

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Uniprot Description

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.

Research Articles on NFATC2

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Product Notes

The NFATC2 nfatc2 (Catalog #AAA206821) is a Recombinant Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. The tag for this protein is His-tag. AAA Biotech's NFATC2 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the NFATC2 nfatc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: PLEWPLSSQS GSYELRIEVQ PKPHHRAHYE TEGSRGAVKA PTGGHPVVQL HGYMENKPLG LQIFIGTADE RILKPHAFYQ VHRITGKTVT TTSYEKIVGN TKVLEIPLEP KNNMRATIDC AGILKLRNAD IELRKGETDI GRKNTRVRLV FRVHIPESSG RIVSLQTASN PIECSQRSAH ELPMVERQDT DSCLVYGGQQ MILTGQNFTS ESKVVFTEKT TDGQQIWEME ATVDKDKSQP NMLFVEIPEY RNKHIRTPVK VNFYVINGKR KRSQPQHFTY HPVHHHHHH. It is sometimes possible for the material contained within the vial of "NFATC2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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