KLK13 active protein

KLK13, 17-277aa, Human, His tag, Baculovirus (Bioactivity Validated)

Cat. Num. AAA206207

• Gene Names: KLK13; KLKL4; KLK-L4
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: KLK13; 17-277aa; Human; His tag; Baculovirus (Bioactivity Validated); Kallikrein-13; KLK-L4; KLKL4; KLK13 active protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: GGVSQESSKV LNTNGTSGFL PGGYTCFPHS QPWQAALLVQ GRLLCGGVLV HPKWVLTAAH CLKEGLKVYL GKHALGRVEA GEQVREVVHS IPHPEYRRSP THLNHDHDIM LLELQSPVQL TGYIQTLPLS HNNRLTPGTT CRVSGWGTTT SPQVNYPKTL QCANIQLRSD EECRQVYPGK ITDNMLCAGT KEGGKDSCEG DSGGPLVCNR TLYGIVSWGD FPCGQPDRPG VYTRVSRYVL WIRETIRKYE TQQQKWLKGP QHHHHHH
• Sequence Length: 277

• Applicable Applications for KLK13 active protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Biological Activity: Specific activity is > 8,000 pmol/min/ug. One unit will hydrolyze 1.0 pmole of BAEE to Na-Benzoyl-L-arginine per minute at pH8.0 at 25C.
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for KLK13 active protein

KLK13, also known as kallikrein-13, belongs to Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK13 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. Recombinant human KLK13, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for KLK13 active protein

Signal Transduction; Enzymes & Proteases

References

Yousef G.M. et al., (2000) J. Biol. Chem. 275:11891-11898.; Diamandis EP. et al., (2000) Trends Endocrinol. Metab. 11:54-60.

NCBI and Uniprot Product Information

• NCBI GI #: 11496281
• NCBI GeneID: 26085
• NCBI Accession #: NP_056411
• NCBI GenBank Nucleotide #: NM_015596.2
• UniProt Accession #: Q9UKR3; Q86VI8; Q9Y433; A7UNK6
• Molecular Weight: 29.7kDa (267aa) 28-40KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: kallikrein-13 isoform 1
• NCBI Official Synonym Full Names: kallikrein related peptidase 13
• NCBI Official Symbol: KLK13
• NCBI Official Synonym Symbols: KLKL4; KLK-L4
• NCBI Protein Information: kallikrein-13
• UniProt Protein Name: Kallikrein-13
• Protein Family: Kallikrein
• UniProt Gene Name: KLK13
• UniProt Synonym Gene Names: KLKL4; KLK-L4

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]