Von Willebrand Factor Cleaving Protease Recombinant Protein | vWFCP recombinant protein

Recombinant Von Willebrand Factor Cleaving Protease (vWFCP)

Cat. Num. AAA2034304

• Gene Names: ADAMTS13; VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13
• Reactivity: Human
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Von Willebrand Factor Cleaving Protease; Recombinant Von Willebrand Factor Cleaving Protease (vWFCP); ADAMTS13; TTP; vWF-cp; vWF-cleaving protease; A Disintegrin And Metalloproteinase With A Thrombospondin Type 1 Motif Member 13; vWFCP recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: >95%
• Sequence Length: 1427

• Applicable Applications for vWFCP recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Pro682~Cys859
• Tag: Prokaryotic expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 16306598
• NCBI GeneID: 11093
• Molecular Weight: 22.3kDa
• NCBI Official Full Name: von Willebrand factor-cleaving protease
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif 13
• NCBI Official Symbol: ADAMTS13
• NCBI Official Synonym Symbols: VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 13
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 13
• UniProt Gene Name: ADAMTS13
• UniProt Synonym Gene Names: C9orf8; ADAM-TS 13; ADAM-TS13; ADAMTS-13; vWF-CP; vWF-cleaving protease
• UniProt Entry Name: ATS13_HUMAN

NCBI Description

This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Calcium-binding; Secreted; Extracellular matrix; Protease; Secreted, signal peptide; EC 3.4.24.87

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular space; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; integrin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; zinc ion binding

Biological Process: cell-matrix adhesion; cellular protein metabolic process; glycoprotein metabolic process; integrin-mediated signaling pathway; peptide catabolic process; platelet activation; post-translational protein modification; protein amino acid O-linked glycosylation; protein processing; proteolysis; response to toxin

Disease: Thrombotic Thrombocytopenic Purpura, Congenital