Stathmin Recombinant Protein | STMN1 recombinant protein

Stathmin, 1-149aa, Human, His tag, E Coli

Cat. Num. AAA203211

• Gene Names: STMN1; Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: Stathmin; 1-149aa; Human; His tag; E Coli; STMN1; Phosphoprotein p19 (pp19); Oncoprotein 18 (Op18); pp17; Prosolin; Metablastin; LAP18; Lag; LAP 18; Leukemia associated phosphoprotein p18; Oncoprotein 18; OP 18; OP18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; PP19; PR22; Pr22 protein; Protein Pr22; SMN; Stathmin1; STMN 1.; STMN1 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD
• Sequence Length: 149

• Applicable Applications for STMN1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for STMN1 recombinant protein

Stathmin is a ubiquitous phosphoprotein proposed to play a general role as an intracellular relay integrating diverse regulatory signals of the cellular environment. Also, Stathmin protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. The role of Stathmin in regulation of the cell cycle causes it to be an oncoprotein (Oncoprotein 18, op18). When Stathmin is mutated and not functioning properly, this protein can cause uncontrolled cell proliferation. Recombinant human Stathmin protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for STMN1 recombinant protein

Cell Cycle

References

Maucuer A., et al. (1990). FEBS Lett. 264 (2):275-8; Sobel A., et al. (1991). Trends Biochem Sci. 16 (8):301-5 ; Steinmetz MO., et al. (2007). J Struct Biol. 158 (2):137-47;

NCBI and Uniprot Product Information

• NCBI GI #: 44890050
• NCBI GeneID: 3925
• NCBI Accession #: NP_981944
• NCBI GenBank Nucleotide #: NM_203399.1
• UniProt Accession #: P16949; A2A2D1; B2R4E7; B7Z8N4; D3DPJ5
• Molecular Weight: 19.4 kDa (169aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: stathmin isoform a
• NCBI Official Synonym Full Names: stathmin 1
• NCBI Official Symbol: STMN1
• NCBI Official Synonym Symbols: Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• NCBI Protein Information: stathmin
• UniProt Protein Name: Stathmin
• Protein Family: Stathmin
• UniProt Gene Name: STMN1
• UniProt Synonym Gene Names: C1orf215; LAP18; OP18; Op18; pp19

NCBI Description

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear ().