Platelet Derived Growth Factor Receptor Like Protein Recombinant Protein | PDGFRL recombinant protein

Recombinant Platelet Derived Growth Factor Receptor Like Protein (PDGFRL)

Cat. Num. AAA2030377

• Gene Names: PDGFRL; PDGRL; PRLTS
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Platelet Derived Growth Factor Receptor Like Protein; Recombinant Platelet Derived Growth Factor Receptor Like Protein (PDGFRL); PDGFRL recombinant protein

• Host: Host: E Coli; Source: Prokaryotic expression
• Purity/Purification: >95%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.; QHLPKNKRP KEPGENRIKP TNKKVKPKIPKMKDRDSANS APKTQSIMMQ VLDKGRFQKP AATLSLLAGQ TVELRCKGSRIGWSYPAYLD TFKDSRLSVK QNERYGQLTL VNSTSADTGE FSCWVQLCSGYICRKDEAKT GSTYIFFTEK GELFVPSPSY FDVVYLNPDR QAVVPCRVTVLSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSEH QGVVYCRAEAGGRSQISVKY QLLYVAVPSG PPSTTILASS NKVKSGDDIS VLCTVLGEPDVEVEFTWIFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VITVEDFETIDAGYYICTAQ NLQGQTTVAT TVEFS
• Sequence Length: 375

• Applicable Applications for PDGFRL recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Predicted Molecular Mass: 69.5kDa
• Accurate Molecular Mass (KD): 70kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Tag: two N-terminal Tags, His-tag and GST-tag
• Organism Species: Homo sapiens (Human)
• Fragment: Gln22~Ser375
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 5453872
• NCBI GeneID: 5157
• NCBI Accession #: NP_006198.1
• NCBI GenBank Nucleotide #: NM_006207.2
• Molecular Weight: 41,861 Da
• NCBI Official Full Name: platelet-derived growth factor receptor-like protein
• NCBI Official Synonym Full Names: platelet-derived growth factor receptor-like
• NCBI Official Symbol: PDGFRL
• NCBI Official Synonym Symbols: PDGRL; PRLTS
• NCBI Protein Information: platelet-derived growth factor receptor-like protein
• UniProt Protein Name: Platelet-derived growth factor receptor-like protein
• Protein Family: Platelet-derived growth factor receptor-like protein
• UniProt Gene Name: PDGFRL
• UniProt Synonym Gene Names: PRLTS; PDGFR-like protein
• UniProt Entry Name: PGFRL_HUMAN

NCBI Description

This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]

Uniprot Description

PDGFRL: Defects in PDGFRL are associated with colorectal cancer (CRC).

Protein type: Receptor, misc.; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p22-p21.3

Cellular Component: extracellular region

Molecular Function: platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway

Disease: Hepatocellular Carcinoma