Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Neuron Derived Orphan Receptor 1 Polyclonal Antibody | anti-NOR1 antibody
Polyclonal Antibody to Neuron Derived Orphan Receptor 1 (NOR1)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
NCBI and Uniprot Product Information
NCBI Description
nuclear orphan receptor; involved in regulating transcription [RGD, Feb 2006]
Uniprot Description
NR4A3: Binds to the B1A response-element. Defects in NR4A3 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1. A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. Belongs to the nuclear hormone receptor family. NR4 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Nuclear receptor; Oncoprotein
Chromosomal Location of Human Ortholog: 5q22
Cellular Component: mast cell granule; nucleus; transcription factor complex
Molecular Function: DNA binding; glucocorticoid receptor binding; histone acetyltransferase binding; ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; protein kinase binding; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process: adult behavior; axon guidance; cellular respiration; fat cell differentiation; gastrulation; hippocampus development; inner ear morphogenesis; intracellular receptor signaling pathway; mast cell degranulation; mesoderm formation; negative regulation of apoptosis; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; neuromuscular process controlling balance; organ regeneration; positive regulation of cell cycle; positive regulation of epithelial cell proliferation; positive regulation of fatty acid oxidation; positive regulation of mast cell cytokine production; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; pyruvate oxidation; regulation of smooth muscle cell proliferation; response to hydrogen peroxide; response to peptide hormone; semicircular canal morphogenesis; steroid hormone mediated signaling; transcription from RNA polymerase II promoter; vestibular reflex
Research Articles on NOR1
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Product Notes
The NOR1 nr4a3 (Catalog #AAA2028443) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Neuron Derived Orphan Receptor 1 (NOR1) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Neuron Derived Orphan Receptor 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the NOR1 nr4a3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Neuron Derived Orphan Receptor 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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