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Sequence Information

Catenin Beta Interacting Protein 1 (CTNNbIP1) Recombinant Protein | CTNNbIP1 recombinant protein

Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1)

Gene Names
CTNNBIP1; ICAT
Reactivity
Human
Applications
SDS-Page, Western Blot, ELISA, Immunoprecipitation, Immunoprecipitation
Purity
>92%
Synonyms
Catenin Beta Interacting Protein 1 (CTNNbIP1); Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1); CTNNbIP1 recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Reactivity
Human
Purity/Purification
>92%
Form/Format
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
Concentration
200ug/mL (varies by lot)
Applicable Applications for CTNNbIP1 recombinant protein
SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.

(May be suitable for use in other assays to be determined by the end user.)
Source
Prokaryotic expression
Residues
Met1~Gln81
Tags
N-terminal His-Tag
Tissue Specificity
Brain, Lung, Heart
Subcellular Location
Cytoplasm. Nucleus
Traits
Freeze-dried powder
Predicted isoelectric point
6.7
Predicted Molecular Mass
12.9kDa
Accurate Molecular Mass
13kDa as determined by SDS-PAGE reducing conditions
Usage
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Sequence Information

Sequence Information

SDS-Page

SDS-Page

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
beta-catenin-interacting protein 1
NCBI Official Synonym Full Names
catenin, beta interacting protein 1
NCBI Official Symbol
CTNNBIP1
NCBI Official Synonym Symbols
ICAT
NCBI Protein Information
beta-catenin-interacting protein 1; inhibitor of beta-catenin and Tcf-4; beta-catenin-interacting protein ICAT
UniProt Protein Name
Beta-catenin-interacting protein 1
UniProt Gene Name
CTNNBIP1
UniProt Synonym Gene Names
ICAT
UniProt Entry Name
CNBP1_HUMAN

NCBI Description

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family.

Protein type: Inhibitor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; cytoplasm; nucleus; beta-catenin destruction complex; cytosol

Molecular Function: protein binding; beta-catenin binding

Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; negative regulation of smooth muscle cell proliferation; ureteric bud branching; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding

Research Articles on CTNNbIP1

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Product Notes

The CTNNbIP1 ctnnbip1 (Catalog #AAA2018359) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Catenin Beta Interacting Protein 1 (CTNNbIP1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Catenin Beta Interacting Protein 1 (CTNNbIP1) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.) . Researchers should empirically determine the suitability of the CTNNbIP1 ctnnbip1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Catenin Beta Interacting Protein 1 (CTNNbIP1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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