FK506 Binding Protein 10 (FKBP10) Recombinant Protein | FKBP10 recombinant protein

Recombinant FK506 Binding Protein 10 (FKBP10)

Cat. Num. AAA2011578

• Gene Names: Fkbp10; Fkbp6; FKBP65; Fkbprp; FKBP-10; FKBP-65; AI325255; Fkbp-rs1; Fkbp1-rs
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: FK506 Binding Protein 10 (FKBP10); Recombinant FK506 Binding Protein 10 (FKBP10); FKBP10 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSG SEF-VGQGY IIPGMDQGLQ GACIGERRRI TVPPHLAYGE NGTGDKIPGS AVLIFDVHVI DFHNPSDPVE IKTLSRPPEN CNETSKIGDF IRYHYNCSLL DGTRLFSSHD YEAPQEITLG ANKVIEGLDR GLQGMCVGER RQLIVPPHLA HGENGARGVP GSAVLLFEVE LVSREDGLPT GYLFVWYQDP STSLFEDMDL NKDGEVPPEE FSSFIKAQVN EGKGRLMPGQ DPDKTISDMF QNQDRNQDGK ITAEELKLKS DED
• Sequence Length: 581

• Applicable Applications for FKBP10 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Mus musculus (Mouse)
• Expression System: Prokaryotic expression
• Residues: Val316~Asp573 (Accession # Q61576) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

Sequence Information

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 254939534
• NCBI GeneID: 14230
• NCBI Accession #: NP_034351.2
• NCBI GenBank Nucleotide #: NM_010221.2
• UniProt Accession #: Q61576; Q8VHI1; A2A4I0
• Molecular Weight: 30.0kDa
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1
• NCBI Official Synonym Full Names: FK506 binding protein 10
• NCBI Official Symbol: Fkbp10
• NCBI Official Synonym Symbols: Fkbp6; FKBP65; Fkbprp; FKBP-10; FKBP-65; AI325255; Fkbp-rs1; Fkbp1-rs
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP10; rotamase; 65 kDa FKBP; PPIase FKBP10; immunophilin FKBP65; FK506-binding protein 10; 65 kDa FK506-binding protein; FK506 binding protein 6 (65 kDa)
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP10
• Protein Family: Peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: Fkbp10
• UniProt Synonym Gene Names: Fkbp-rs; Fkbp1-rs; Fkbp6; Fkbp65; Fkbprp; PPIase FKBP10; 65 kDa FKBP; FKBP-65; FKBP-10
• UniProt Entry Name: FKB10_MOUSE

Uniprot Description

FKBP10: PPIases accelerate the folding of proteins during protein synthesis. Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6). OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass.

Protein type: EC 5.2.1.8; Isomerase

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; metal ion binding; isomerase activity; calcium ion binding

Biological Process: protein peptidyl-prolyl isomerization; protein folding