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Hexosaminidase B Beta (HEXb) Recombinant Protein | HEXb recombinant protein
Recombinant Hexosaminidase B Beta (HEXb)
MGHHHHHHSGSEF- KTQVFGP VDPTVNTTYA FFNTFFKEIS SVFPDQFIHL GGDEVEFQCW ASNPNIQGFM KRKGFGSDFR RLESFYIKKI LEIISSLKKN SIVWQEVFDD KVELQPGTVV EVWKSEHYSY ELKQVTGSGF PAILSAPWYL DLISY
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
Uniprot Description
HEXB: Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. Defects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2); also known as Sandhoff disease. GM2- gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2- gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula. Belongs to the glycosyl hydrolase 20 family.
Protein type: Glycan Metabolism - other glycan degradation; EC 3.2.1.52; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; Carbohydrate Metabolism - amino sugar and nucleotide sugar
Cellular Component: membrane; lysosome; cell; acrosome
Molecular Function: beta-N-acetylglucosaminidase activity; protein homodimerization activity; hexosaminidase activity; hydrolase activity; protein heterodimerization activity; beta-N-acetylhexosaminidase activity; hydrolase activity, acting on glycosyl bonds; carbohydrate binding; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: male courtship behavior; myelination; oogenesis; glycosaminoglycan metabolic process; ganglioside catabolic process; metabolic process; locomotory behavior; regulation of cell shape; sequestering of lipid; oligosaccharide catabolic process; sensory perception of sound; single fertilization; penetration of zona pellucida; neuromuscular process controlling balance; skeletal development; neuromuscular process; N-acetylglucosamine metabolic process; phospholipid biosynthetic process; cellular calcium ion homeostasis; cellular protein metabolic process; sexual reproduction; lysosome organization and biogenesis; carbohydrate metabolic process; glycosphingolipid metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cellular metabolic process; astrocyte cell migration
Research Articles on HEXb
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Product Notes
The HEXb hexb (Catalog #AAA2011431) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Hexosaminidase B Beta (HEXb) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the HEXb hexb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF- KTQVFGP VDPTVNTTYA FFNTFFKEIS SVFPDQFIHL GGDEVEFQCW ASNPNIQGFM KRKGFGSDFR RLESFYIKKI LEIISSLKKN SIVWQEVFDD KVELQPGTVV EVWKSEHYSY ELKQVTGSGF PAILSAPWYL DLISY. It is sometimes possible for the material contained within the vial of "Hexosaminidase B Beta (HEXb), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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