Colony Stimulating Factor Receptor, Granulocyte (GCSFR) Recombinant Protein | GCSFR recombinant protein

Recombinant Colony Stimulating Factor Receptor, Granulocyte (GCSFR)

Cat. Num. AAA2010223

• Gene Names: CSF3R; CD114; GCSFR
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Colony Stimulating Factor Receptor; Granulocyte (GCSFR); Recombinant Colony Stimulating Factor Receptor; GCSFR recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGSEF-CGHISVSAPI VHLGDPITAS CIIKQNCSHL DPEPQILWRL GAELQPGGRQ QRLSDGTQES IITLPHLNHT QAFLSCCLNW GNSLQILDQV ELRAGYPPAI PHNLSCLMNL TTS
• Sequence Length: 836

• Applicable Applications for GCSFR recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Cys26~Ser138 (Accession # Q99062) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

NCBI and Uniprot Product Information

• NCBI GI #: 4503081
• NCBI GeneID: 1441
• NCBI Accession #: NP_000751.1
• NCBI GenBank Nucleotide #: NM_000760.3
• UniProt Accession #: Q99062
• Molecular Weight: 13.8kDa
• NCBI Official Full Name: granulocyte colony-stimulating factor receptor isoform a
• NCBI Official Synonym Full Names: colony stimulating factor 3 receptor (granulocyte)
• NCBI Official Symbol: CSF3R
• NCBI Official Synonym Symbols: CD114; GCSFR
• NCBI Protein Information: granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor
• UniProt Protein Name: Granulocyte colony-stimulating factor receptor
• UniProt Gene Name: CSF3R
• UniProt Synonym Gene Names: GCSFR; G-CSF receptor; G-CSF-R
• UniProt Entry Name: CSF3R_HUMAN

NCBI Description

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]

Uniprot Description

GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1p35-p34.3

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity

Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; cell adhesion; signal transduction

Disease: Neutrophilia, Hereditary