Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Recombinant Protein | FRS2 recombinant protein

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2)

Cat. Num. AAA2009677

• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Fibroblast Growth Factor Receptor Substrate 2 (FRS2); Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2); FRS2 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- LEQ LGKDQVSGSG ASSTEWDTGY DSDERRDVPP VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRPALLNYE NLPSLPPVWE ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV PASAHKIDCS RRRDCTPTVF NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP QTP
• Sequence Length: 508

• Applicable Applications for FRS2 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Rattus norvegicus (Rat)
• Expression System: Prokaryotic expression
• Residues: Leu268~Pro453 (Accession # D4A244) with two N-terminal Tags, His-tag and T7-tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 184160980
• NCBI GeneID: 314850
• NCBI Accession #: NP_001101567.2
• NCBI GenBank Nucleotide #: NM_001108097.3
• UniProt Accession #: D4A244
• Molecular Weight: 24.6kDa
• NCBI Official Full Name: fibroblast growth factor receptor substrate 2
• NCBI Official Synonym Full Names: fibroblast growth factor receptor substrate 2
• NCBI Official Symbol: Frs2
• NCBI Protein Information: fibroblast growth factor receptor substrate 2
• UniProt Protein Name: Fibroblast growth factor receptor substrate 2 (Predicted), isoform CRA_b
• Protein Family: Fibroblast growth factor receptor substrate
• UniProt Gene Name: Frs2
• UniProt Synonym Gene Names: Frs2_predicted
• UniProt Entry Name: D4A244_RAT

Uniprot Description

FRS2: an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

Protein type: Adaptor/scaffold

Cellular Component: cytoplasm; plasma membrane; intercellular junction

Molecular Function: neurotrophin TRKA receptor binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding; fibroblast growth factor receptor binding

Biological Process: lens development in camera-type eye; fibroblast growth factor receptor signaling pathway; positive regulation of signal transduction; activation of MAPK activity; gastrulation with mouth forming second; regulation of epithelial cell proliferation; regulation of apoptosis; induction of an organ; determination of anterior/posterior axis, embryo; neuroblast proliferation; forebrain development; optic placode formation involved in camera-type eye; transmembrane receptor protein tyrosine kinase signaling pathway