Interleukin 1 Receptor Type I (IL1R1) Recombinant Protein | IL1R1 recombinant protein
Recombinant Interleukin 1 Receptor Type I (IL1R1)
MGHHHHHHSGSEF-DSCSDFLPRK ASDGRTYDAY VLYPKTYGEG SFAYLDTFVF KLLPEVLEGQ FGYKLFICGR DDYVGEDTIE VTNENVKRSR RLIIILVRDM GSFSCLGQSS EEQIAIYDAL IREGIKIILL ELEKIQDYEK MPESIQFIKQ KHGAICWSGD FKERPQSAKT RFWKNLRY
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
NCBI Description
receptor for interleukin-1; involved in inflammatory response signalling [RGD, Feb 2006]
Uniprot Description
Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex
By similarity.
Subunit structure: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1
By similarity.
Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane
Probable. Secreted
By similarity.
Post-translational modification: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding)
By similarity.Rapidely phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1
By similarity.
Sequence similarities: Belongs to the interleukin-1 receptor family.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 TIR domain.
Sequence caution: The sequence AAA16196.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on IL1R1
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Product Notes
The IL1R1 il1r1 (Catalog #AAA2009213) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Interleukin 1 Receptor Type I (IL1R1) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the IL1R1 il1r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-DSCSDF LPRK ASDGRTYDAY VLYPKTYGEG SFAYLDTFVF KLLPEVLEGQ FGYKLFICGR DDYVGEDTIE VTNENVKRSR RLIIILVRDM GSFSCLGQSS EEQIAIYDAL IREGIKIILL ELEKIQDYEK MPESIQFIKQ KHGAICWSGD FKERPQSAKT RFWKNLRY. It is sometimes possible for the material contained within the vial of "Interleukin 1 Receptor Type I (IL1R1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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