TADA3 cdna clone
TADA3
Translation Sequence: MSELKDCPLQ FHDFKSVDHL KVCPRYTAVL ARSEDDGIGI EELDTLQLEL ETLLSSASRRLRVLEAETQI LTDWQDKKGD RRFLKLGRDH ELGAPPKHGK PKKQKLEGKA GHGPGPGPGRPKSKNLQPKI QEYEFTDDPI DVPRIPKNDA PNRFWASVEP YCADITSEEV RTLEELLKPPEDEAEHYKIP PLGKHYSQRW AQEDLLEEQK DGARAAAVAD KKKGLMGPLT ELDTKDVDALLKKSEAQHEQ PEDGCPFGAL TQRLLQALVE ENIISPMEDS PIPDMSGKES GADGASTSPRNQNKPFSVPH TKSLESRIKE ELIAQGLLES EDRPAEDSED EVLAELRKRQ AELKALSAHNRTKKHDLLRL AKEEVSRQEL RQRVRMADNE VMDAFRKIMA ARQKKRTPTK KEKDQAWKTLKERESILKLL DG
NCBI and Uniprot Product Information
NCBI Description
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Uniprot Description
TADA3L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Belongs to the NGG1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: nucleoplasm; intracellular; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; protein domain specific binding; protein binding; histone acetyltransferase activity; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; mitosis; regulation of histone deacetylation; regulation of protein amino acid phosphorylation; establishment and/or maintenance of chromatin architecture; estrogen receptor signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of protein stability
Research Articles on TADA3
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Product Notes
The TADA3 tada3 (Catalog #AAA200896) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGAGTGAGT TGAAAGACTG CCCCTTGCAG TTCCACGACT TCAAGTCTGT GGATCACCTG AAGGTCTGTC CCCGCTACAC GGCAGTGCTG GCACGCTCTG AGGATGATGG CATCGGCATC GAGGAGCTGG ACACCCTGCA GCTGGAGCTG GAGACCCTGC TGTCTTCTGC CAGCCGGCGC CTGCGTGTGC TTGAGGCCGA AACCCAGATC CTCACCGACT GGCAGGATAA GAAAGGTGAC AGACGATTCC TGAAGCTGGG TCGAGACCAT GAACTTGGAG CTCCCCCCAA ACATGGGAAG CCCAAGAAGC AGAAACTGGA AGGGAAGGCA GGACATGGGC CGGGCCCTGG CCCAGGACGG CCCAAATCCA AAAACCTTCA GCCCAAGATC CAGGAATATG AATTCACTGA TGACCCTATC GACGTGCCAC GGATCCCCAA AAATGATGCC CCCAACAGGT TCTGGGCTTC AGTGGAGCCC TACTGTGCTG ACATCACCAG CGAGGAGGTC CGCACACTTG AGGAGTTACT GAAGCCCCCA GAAGATGAGG CTGAGCATTA CAAGATCCCA CCCCTGGGGA AGCACTACTC CCAGCGCTGG GCCCAGGAGG ACCTGCTGGA GGAGCAGAAG GATGGGGCCC GGGCAGCGGC TGTGGCTGAC AAGAAGAAAG GCCTCATGGG GCCACTGACC GAACTGGACA CTAAAGATGT GGATGCCCTG CTGAAGAAGT CTGAGGCCCA GCATGAACAG CCGGAAGATG GATGCCCCTT TGGTGCCCTG ACGCAGCGCC TCCTGCAGGC CCTGGTGGAG GAAAATATTA TTTCCCCTAT GGAGGATTCT CCTATTCCTG ACATGTCTGG GAAAGAATCA GGGGCTGACG GGGCAAGCAC CTCCCCTCGC AATCAGAACA AGCCCTTCAG TGTGCCGCAT ACTAAGTCCC TGGAGAGCCG CATCAAGGAG GAGCTAATTG CCCAGGGCCT TTTGGAGTCT GAGGACCGCC CCGCAGAGGA CTCCGAGGAT GAGGTCCTTG CTGAGCTTCG CAAACGGCAG GCTGAGCTGA AGGCACTTAG TGCCCACAAC CGCACCAAGA AGCACGACCT GCTGAGGCTG GCAAAGGAGG AGGTGAGCCG GCAGGAGCTG AGGCAGCGGG TGCGCATGGC TGACAACGAG GTCATGGACG CCTTTCGCAA GATCATGGCT GCCCGGCAGA AGAAGCGGAC TCCCACCAAG AAAGAAAAGG ACCAGGCCTG GAAGACTCTG AAGGAGCGTG AGAGCATCCT GAAGCTGCTG GATGGGTAG< br> Tra nslation Sequence: MSELKDCPLQ FHDFKSVDHL KVCPRYTAVL ARSEDDGIGI EELDTLQLEL ETLLSSASRR LRVLEAETQI LTDWQDKKGD RRFLKLGRDH ELGAPPKHGK PKKQKLEGKA GHGPGPGPGR PKSKNLQPKI QEYEFTDDPI DVPRIPKNDA PNRFWASVEP YCADITSEEV RTLEELLKPP EDEAEHYKIP PLGKHYSQRW AQEDLLEEQK DGARAAAVAD KKKGLMGPLT ELDTKDVDAL LKKSEAQHEQ PEDGCPFGAL TQRLLQALVE ENIISPMEDS PIPDMSGKES GADGASTSPR NQNKPFSVPH TKSLESRIKE ELIAQGLLES EDRPAEDSED EVLAELRKRQ AELKALSAHN RTKKHDLLRL AKEEVSRQEL RQRVRMADNE VMDAFRKIMA ARQKKRTPTK KEKDQAWKTL KERESILKLL DG. It is sometimes possible for the material contained within the vial of "TADA3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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