RBPMS cdna clone

RBPMS

Cat. Num. AAA200853

• Gene Names: RBPMS; HERMES
• Synonyms: RBPMS; HERMES; RBPMS cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGAACAACGGCGGCAAAGCCGAGAAGGAGAACACCCCGAGCGAGGCCAACCTTCAGGAGGAGGAGGTCCGGACCCTATTTGTCAGTGGCCTTCCTCTGGATATCAAACCTCGGGAGCTCTATCTGCTTTTCAGACCATTTAAGGGCTATGAGGGTTCTCTTATAAAGCTCACATCTAAACAGCCTGTAGGTTTTGTCAGTTTTGACAGTCGCTCAGAAGCAGAGGCTGCAAAGAATGCTTTGAATGGCATCCGCTTCGATCCTGAAATTCCGCAAACACTACGACTAGAGTTTGCTAAGGCAAACACGAAGATGGCCAAGAACAAACTCGTAGGGACTCCAAACCCCAGTACTCCTCTGCCCAACACTGTACCTCAGTTCATTGCCAGAGAGCCATATGAGCTCACAGTGCCTGCACTTTACCCCAGTAGCCCTGAAGTGTGGGCCCCGTACCCTCTGTACCCAGCGGAGTTAGCGCCTGCTCTACCTCCTCCTGCTTTCACCTATCCCGCTTCACTGCATGCCCAGATGCGCTGGCTCCCTCCCTCCGAGGCTACTTCTCAGGGCTGGAAGTCCCGTCAGTTCTGCTGA; ; Translation Sequence: MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL PNTVPQFIAR EPYELTVPAL YPSSPEVWAP YPLYPAELAP ALPPPAFTYP ASLHAQMRWL PPSEATSQGW KSRQFC
• Sequence Length: 196

• Species: Human
• Chromosome Location: 8p12
• OMIM Reference Number: 601558
• cDNA Size: 591bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for RBPMS cdna clone

RBPMS encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.

Product Categories/Family for RBPMS cdna clone

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 57164969
• NCBI GeneID: 11030
• NCBI Accession #: NP_001008710.1
• NCBI GenBank Nucleotide #: NM_001008710.2
• UniProt Accession #: Q93062
• NCBI Official Full Name: RNA-binding protein with multiple splicing isoform A
• NCBI Official Synonym Full Names: RNA binding protein, mRNA processing factor
• NCBI Official Symbol: RBPMS
• NCBI Official Synonym Symbols: HERMES
• NCBI Protein Information: RNA-binding protein with multiple splicing
• UniProt Protein Name: RNA-binding protein with multiple splicing
• Protein Family: RNA-binding protein with multiple splicing
• UniProt Gene Name: RBPMS
• UniProt Synonym Gene Names: HERMES; RBP-MS; Hermes
• UniProt Entry Name: RBPMS_HUMAN

NCBI Description

This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Uniprot Description

RBPMS: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; transcription coactivator activity; nucleotide binding; poly(A) binding

Biological Process: RNA processing; regulation of transcription, DNA-dependent; transcription, DNA-dependent