CDKN3 cdna clone
CDKN3
Translation Sequence: MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNVQKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCCEIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAIQTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR
NCBI and Uniprot Product Information
Uniprot Description
CDKN3: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.16; Cell cycle regulation; EC 3.1.3.48
Chromosomal Location of Human Ortholog: 14q22
Cellular Component: perinuclear region of cytoplasm; cytoplasm
Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity
Biological Process: negative regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle
Disease: Hepatocellular Carcinoma
Similar Products
Product Notes
The CDKN3 cdkn3 (Catalog #AAA200717) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGAAGCCGC CCAGTTCAAT ACAAACAAGT GAGTTTGACT CATCAGATGA AGAGCCTATT GAAGATGAAC AGACTCCAAT TCATATATCA TGGCTATCTT TGTCACGAGT GAATTGTTCT CAGTTTCTCG GTTTATGTGC TCTTCCAGGT TGTAAATTTA AAGATGTTAG AAGAAATGTC CAAAAAGATA CAGAAGAACT AAAGAGCTGT GGTATACAAG ACATATTTGT TTTCTGCACC AGAGGGGAAC TGTCAAAATA TAGAGTCCCA AACCTTCTGG ATCTCTACCA GCAATGTGGA ATTATCACCC ATCATCATCC AATCGCAGAT GGAGGGACTC CTGACATAGC CAGCTGCTGT GAAATAATGG AAGAGCTTAC AACCTGCCTT AAAAATTACC GAAAAACCTT AATACACTGC TATGGAGGAC TTGGGAGATC TTGTCTTGTA GCTGCTTGTC TCCTACTATA CCTGTCTGAC ACAATATCAC CAGAGCAAGC CATAGACAGC CTGCGAGACC TAAGAGGATC CGGGGCAATA CAGACCATCA AGCAATACAA TTATCTTCAT GAGTTTCGGG ACAAATTAGC TGCACATCTA TCATCAAGAG ATTCACAATC AAGATCTGTA TCAAGATAA< br> Tra nslation Sequence: MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR. It is sometimes possible for the material contained within the vial of "CDKN3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.