COMMD1 cdna clone

COMMD1

Cat. Num. AAA200629

• Gene Names: COMMD1; MURR1; C2orf5
• Synonyms: COMMD1; C2orf5; MURR1; COMMD1 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGCGGCGGGCGAGCTTGAGGGTGGCAAACCCCTGAGCGGGCTGCTGAATGCGCTGGCCCAGGACACTTTCCACGGGTACCCCGGCATCACAGAGGAGCTGCTACGGAGCCAGCTATATCCAGAGGTGCCACCCGAGGAGTTCCGCCCCTTTCTGGCAAAGATGAGGGGGATTCTTAAGTCTATTGCGTCTGCAGACATGGATTTCAACCAGCTGGAGGCATTCTTGACTGCTCAAACCAAAAAGCAAGGTGGGATCACATCTGACCAAGCTGCTGTCATTTCCAAATTCTGGAAGAGCCACAAGACAAAAATCCGTGAGAGCCTCATGAACCAGAGCCGCTGGAATAGCGGGCTTCGGGGCCTGAGCTGGAGAGTTGATGGCAAGTCTCAGTCAAGGCACTCAGCTCAAATACACACACCTGTTGCCATTATAGAGCTGGAATTAGGCAAATATGGACAGGAATCTGAATTTCTGTGTTTGGAATTTGATGAGGTCAAAGTCAACCAAATTCTGAAGACGCTGTCAGAGGTAGAAGAAAGTATCAGCACACTGATCAGCCAGCCTAACTGA; ; Translation Sequence: MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN
• Sequence Length: 190

• Species: Human
• Chromosome Location: 2p15
• OMIM Reference Number: 607238
• cDNA Size: 573bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Product Categories/Family for COMMD1 cdna clone

Signal Transduction; Metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 22749079
• NCBI GeneID: 150684
• NCBI Accession #: NP_689729.1
• NCBI GenBank Nucleotide #: NM_152516.2
• UniProt Accession #: Q8N668
• NCBI Official Full Name: COMM domain-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: copper metabolism domain containing 1
• NCBI Official Symbol: COMMD1
• NCBI Official Synonym Symbols: MURR1; C2orf5
• NCBI Protein Information: COMM domain-containing protein 1
• UniProt Protein Name: COMM domain-containing protein 1
• Protein Family: COMM domain-containing protein
• UniProt Gene Name: COMMD1
• UniProt Synonym Gene Names: C2orf5; MURR1
• UniProt Entry Name: COMD1_HUMAN

NCBI Description

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

Uniprot Description

COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Cul2-RING ubiquitin ligase complex; nucleoplasm; recycling endosome; cytoplasm; early endosome; cytoplasmic membrane-bound vesicle; endosome membrane; nucleus

Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; copper ion binding; protein homodimerization activity; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding

Biological Process: Golgi to plasma membrane transport; protein transport; transcription, DNA-dependent; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; regulation of proteasomal ubiquitin-dependent protein catabolic process; plasma membrane to endosome transport; copper ion homeostasis