TAB1 cdna clone

TAB1

Cat. Num. AAA200519

• Gene Names: TAB1; 3'-Tab1; MAP3K7IP1
• Synonyms: TAB1; 3'-Tab1; MAP3K7IP1; TAB1 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGCGGCGC AGAGGAGGAG CTTGCTGCAG AGTGAGCAGC AGCCAAGCTG GACAGATGAC CTGCCTCTCT GCCACCTCTC TGGGGTTGGC TCAGCCTCCA ACCGCAGCTA CTCTGCTGAT GGCAAGGGCA CTGAGAGCCA CCCGCCAGAG GACAGCTGGC TCAAGTTCAG GAGTGAGAAC AACTGCTTCC TGTATGGGGT CTTCAACGGC TATGATGGCA ACCGAGTGAC CAACTTCGTG GCCCAGCGGC TGTCCGCAGA GCTCCTGCTG GGCCAGCTGA ATGCCGAGCA CGCCGAGGCC GATGTGCGGC GTGTGCTGCT GCAGGCCTTC GATGTGGTGG AGAGGAGCTT CCTGGAGTCC ATTGACGACG CCTTGGCTGA GAAGGCAAGC CTCCAGTCGC AATTGCCAGA GGGAGTCCCT CAGCACCAGC TGCCTCCTCA GTATCAGAAG ATCCTTGAGA GACTCAAGAC GTTAGAGAGG GAAATTTCGG GAGGGGCCAT GGCCGTTGTG GCGGTCCTTC TCAACAACAA GCTCTACGTC GCCAATGTCG GTACAAACCG TGCACTTTTA TGCAAATCGA CAGTGGATGG GTTGCAGGTG ACACAGCTGA ACGTGGACCA CACCACAGAG AACGAGGATG AGCTCTTCCG TCTTTCGCAG CTGGGCTTGG ATGCTGGAAA GATCAAGCAG GTGGGGATCA TCTGTGGGCA GGAGAGCACC CGGCGGATCG GGGATTACAA GGTTAAATAT GGCTACACGG ACATTGACCT TCTCAGCGCT GCCAAGTCCA AACCAATCAT CGCAGAGCCA GAAATCCATG GGGCACAGCC GCTGGATGGG GTGACGGGCT TCTTGGTGCT GATGTCGGAG GGGTTGTACA AGGCCCTAGA GGCAGCCCAT GGGCCTGGGC AGGCCAACCA GGAGATTGCT GCGATGATTG ACACTGAGTT TGCCAAGCAG ACCTCCCTGG ACGCAGTGGC CCAGGCCGTC GTGGACCGGG TGAAGCGCAT CCACAGCGAC ACCTTCGCCA GTGGTGGGGA GCGTGCCAGG TTCTGCCCCC GGCACGAGGA CATGACCCTG CTAGTGAGGA ACTTTGGCTA CCCGCTGGGC GAAATGAGCC AGCCCACACC GAGCCCAGCC CCAGCTGCAG GAGGACGAGT GTACCCTGTG TCTGTGCCAT ACTCCAGCGC CCAGAGCACC AGCAAGACCA GCGTGACCCT CTCCCTTGTC ATGCCCTCCC AGGGCCAGAT GGTCAACGGG GCTCACAGTG CTTCCACCCT GGACGAAGCC ACCCCCACCC TCACCAACCA AAGCCCGACC TTAACCCTGC AGTCCACCAA CACGCACACG CAGAGCAGCA GCTCCAGCTC TGACGGAGGC CTCTTCCGCT CCCGGCCCGC CCACTCGCTC CCGCCTGGCG AGGACGGTCG TGTTGAGCCC TATGTGGACT TTGCTGAGTT TTACCGCCTC TGGAGCGTGG ACCATGGCGA GCAGAGCGTG GTGACAGCAC CGTAG; ; Translation Sequence: MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV VTAP
• Sequence Length: 504

• Species: Human
• Chromosome Location: 22q13.1
• OMIM Reference Number: 602615
• cDNA Size: 1515bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for TAB1 cdna clone

TAB1 encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Product Categories/Family for TAB1 cdna clone

immunology; Signal Transduction; cardiovascular; Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 5174703
• NCBI GeneID: 10454
• NCBI Accession #: NP_006107.1
• NCBI GenBank Nucleotide #: NM_006116.2
• UniProt Accession #: Q15750
• NCBI Official Full Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
• NCBI Official Synonym Full Names: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
• NCBI Official Symbol: TAB1
• NCBI Official Synonym Symbols: 3'-Tab1; MAP3K7IP1
• NCBI Protein Information: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• UniProt Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• Protein Family: TGF-beta-activated kinase 1 and MAP3K7-binding protein
• UniProt Gene Name: TAB1
• UniProt Synonym Gene Names: MAP3K7IP1; TAK1-binding protein 1
• UniProt Entry Name: TAB1_HUMAN

NCBI Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

TAB1: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Activator

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; protein complex; cytoplasm; endosome membrane; cytosol

Molecular Function: protein binding; mitogen-activated protein kinase p38 binding; enzyme activator activity; kinase activator activity; protein complex binding; catalytic activity

Biological Process: heart morphogenesis; I-kappaB kinase/NF-kappaB cascade; in utero embryonic development; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; transforming growth factor beta receptor signaling pathway; toll-like receptor signaling pathway; activation of MAPKKK activity; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; lung development