Western Blot (WB)
(Western Blot: Sample: Human Placenta lysate; Primary Ab: 1ug/ml Rabbit Anti-Human NRP1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Human Neuropilin 1 (NRP1) Polyclonal Antibody | anti-NRP1 antibody
Polyclonal Antibody to Neuropilin 1 (NRP1)
MGHHHHHHSGSEF- CGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR GKFCGKIAPP PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKR
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Human Placenta lysate; Primary Ab: 1ug/ml Rabbit Anti-Human NRP1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Human Placenta lysate; Primary Ab: 1ug/ml Rabbit Anti-Human NRP1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
NRP1: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 10p11.22
Cellular Component: axon; cell soma; cell surface; cytoplasmic vesicle; cytosol; early endosome; extracellular space; focal adhesion; growth cone; integral component of membrane; neurofilament; neuron projection; plasma membrane; receptor complex
Molecular Function: coreceptor activity; cytokine binding; growth factor binding; GTPase activator activity; heparin binding; metal ion binding; protein binding; semaphorin receptor activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity
Biological Process: actin cytoskeleton reorganization; angiogenesis; artery morphogenesis; axon extension involved in axon guidance; axon guidance; axonal fasciculation; branching involved in blood vessel morphogenesis; branchiomotor neuron axon guidance; cell migration during sprouting angiogenesis; cell-cell signaling; commissural neuron axon guidance; dendrite arborization; dendrite development; dorsal root ganglion morphogenesis; endothelial cell migration; facial nerve structural organization; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; hepatocyte growth factor receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of axon extension involved in axon guidance; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptosis; nerve development; neural crest cell migration involved in autonomic nervous system development; neuron migration; neuropilin signaling pathway; organ morphogenesis; otic placode development; outflow tract septum morphogenesis; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of actin cytoskeleton reorganization; positive regulation of axon extension involved in axon guidance; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of filopodium formation; positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of retinal ganglion cell axon guidance; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; positive regulation of substrate adhesion-dependent cell spreading; regulation of Cdc42 protein signal transduction; regulation of retinal ganglion cell axon guidance; response to wounding; retinal ganglion cell axon guidance; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in axon guidance; semaphorin-plexin signaling pathway involved in neuron projection guidance; signal transduction; sprouting angiogenesis; substrate-dependent cell migration, cell extension; toxin transport; trigeminal nerve structural organization; vascular endothelial growth factor receptor signaling pathway; VEGF-activated neuropilin signaling pathway; ventral trunk neural crest cell migration; vestibulocochlear nerve structural organization
Research Articles on NRP1
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Product Notes
The NRP1 nrp1 (Catalog #AAA2004751) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Neuropilin 1 (NRP1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Neuropilin 1 (NRP1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the NRP1 nrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- CGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR GKFCGKIAPP PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKR. It is sometimes possible for the material contained within the vial of "Neuropilin 1 (NRP1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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